[OP.7D.10] the Effect of Renal Denervation on Adipokines in Patients With Resistant Hypertension

Eikelis, Nina; Hering, Dagmara; Marušić, Petra; Walton, Antony; Lambert, Elisabeth; Krum, Henry; Lambert, Gavin W.; Esler, M.; Schlaich, Markus

doi:10.1097/01.hjh.0000491585.15776.8e

Cited by 1 publication

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“…Resistant hypertension refers to the case of patient BP remaining >140/90 mmHg following the use of a variety of antihypertensive drugs ( 156 – 158 ). Traditional treatments are not effective, therefore, it is necessary to develop novel therapeutic approaches, and highly selective renal denervation (RDN) is one of these approaches ( 159 – 161 ).…”

Section: Potential Role Of the Thymus In Hypertensionmentioning

confidence: 99%

Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)

Dai

Chen

et al. 2018

Int J Mol Med

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A variety of cells and cytokines have been shown to be involved in the whole process of hypertension. Data from experimental and clinical studies on hypertension have confirmed the key roles of immune cells and inflammation in the process. Dysfunction of the thymus, which modulates the development and maturation of lymphocytes, has been shown to be associated with the severity of hypertension. Furthermore, gradual atrophy, functional decline or loss of the thymus has been revealed to be associated with aging. The restoration or enhancement of thymus function via upregulation in the expression of thymus transcription factors forkhead box N1 or thymus transplantation may provide an option to halt or reverse the pathological process of hypertension. Therefore, the thymus may be key in hypertension and associated target organ damage, and may provide a novel treatment strategy for the clinical management of patients with hypertension in addition to different commercial drugs. The purpose of this review is to summarize and discuss the advances in our understanding of the impact of thymus function on hypertension from data from animal and human studies, and the potential mechanisms.

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