OP0110 Treat-To-Target Recommendations for Spondyloarthritis, Including Ankylosing Spondylitis and Psoriatic Arthritis: A Consensus of an International Task Force

Abstract

Background Therapeutic targets have been defined for diseases like diabetes, hypertension or rheumatoid arthritis and adhering to them has improved outcomes. Such recommendations are unavailable for spondyloarthritis. Objectives To define the treatment target for spondyloarthritis including ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and develop recommendations for achieving the target, including a treat-to-target management strategy. Methods Based on results of a systematic literature review (performed by MS) and expert opinion, a task force of expert physicians and patients developed recommendations, which were broadly discussed and voted upon in a Delphi-like process. Level of evidence, grade of recommendation and strength of recommendation were derived by respective means. Results The literature review did not reveal trials comparing a treat-to-target approach with another or no strategy, but provided indirect evidence that facilitated the development of recommendations. The task force agreed on 5 overarching principles and 11 recommendations. Based on the current perception and classification of spondyloarthritis (including PsA, axial SpA (AS and non-radiographic axial SpA), peripheral SpA), only the last 2 recommendations are separate for axial spondyloarthritis, peripheral spondyloarthritis and PsA, while principles and 9 of the recommendations form a common trunk for all types of spondyloarthritis. The main treatment target, which should be based on a shared decision with the patient, was defined as remission, with an alternative target being low disease activity. Means to assess disease activity are discussed. Regular follow-up examinations should safeguard the evolution of disease activity toward the targeted goal. Additional items relate to extraarticular and extramusculoskeletal aspects and other factors, such as comorbidity. While the level of evidence was low for all items, the mean strength of recommendation was 9-10 (10: maximum agreement) for all recommendations. A research agenda was formulated. Conclusions The recommendations shall inform patients, rheumatologists, dermatologists and other experts as well as other stakeholders about expert opinion that allows reaching optimal outcomes of spondyloarthritis including AS and PsA. Acknowledgements This work was supported by an unrestricted educational grant from Abbott. Disclosure of Interest J. Smolen Grant/research support from: Abbott, Consultant for: Abbott, J. Braun: None Declared, M. Dougados: None Declared, P. Emery: None Declared, O. FitzGerald: None Declared, P. Helliwell: None Declared, A. Kavanaugh: None Declared, T. Kvien: None Declared, R. Landewé: None Declared, T. Luger: None Declared, P. Mease: None Declared, I. Olivieri: None Declared, J. Reveille: None Declared, C. Ritchlin: None Declared, M. Rudwaleit: None Declared, M. Schoels: None Declared, J. Sieper: None Declared, M. de Wit: None Declared, D. van der Heijde: None Declared

Incidence of Anxiety and Depression after Achievement of Inactive/low Disease Activity in Axial/Spondyloarthropathy

“…Radiographs of the sacroiliac joints and the lateral cervical and lumbar spine were performed. Radiographic sacroiliitis was determined according to the Modified New York criteria (bilateral grade 2 or unilateral grade 3–4) 1 . MRI was performed on 1.5T systems.…”

“…The primary goal of treating axial spondiloarthritis is to achieve remission or inactive disease according to treat-to-target recommendations 1 . The most commonly used definition of remission from spondyloarthritis to date has been the ASAS (Assessment of SpondyloArthritis International Society) criterion for partial remission 2 , which includes four domains: patient global, pain, function (BASFI ) and inflammation (mean of the Bath Ankylosing Spondylitis Disease Activity Index – BASDAI questions 5 and 6 ).…”

Update Leitlinie Psoriasisarthritis

“…Hier wäre zum Beispiel der Diabetes mellitus 12 oder auch die arterielle Hypertonie 13 und die Hyperlipidämie zu nennen 14 , bei denen validierte Zielgrößen bekannt sind, die erreicht werden sollen, um sekundäre Komplikationen zu verhindern. In der Rheumatologie wurde erstmals in der rheumatoiden Arthritis (RA) in unterschiedlichen Studienprotokollen gezeigt, dass ein solches Vorgehen das Outcome – unabhängig von der gewählten Therapie – im Vergleich zum Standard of Care deutlich verbessern kann 15 , 16 . In der Folge wurde dies auch für die Psoriasisarthritis nachgewiesen, erstmals durch die hochrangig publizierte Studie TICOPA 17 .…”