Op017 Arginine Appearance and No Synthesis in Critically Ill Children Can Be Increased With a Protein-Energy Enriched Enteral Formula

Betue, C.T. de; Joosten, K.F.; Deutz, N.E.P.; Waardenburg, Dick A. van

doi:10.1016/s1744-1161(12)70018-2

Clinical Nutrition Supplements

2012

DOI: 10.1016/s1744-1161(12)70018-2

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Op017 Arginine Appearance and No Synthesis in Critically Ill Children Can Be Increased With a Protein-Energy Enriched Enteral Formula

C.T. de Betue¹,

K.F. Joosten²,

N.E.P. Deutz³

et al.

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Changes in Arginine Metabolism during Sepsis and Critical Illness in Children

Betue

Deutz²

2013

Nestlé Nutrition Institute Workshop Series

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Arginine is an important amino acid during disease and healing because of functions in the immune system and as precursor of nitric oxide (NO). In critically ill adults and children, plasma arginine and citrulline concentrations are substantially decreased, indicating an arginine-deficient state. Arginine availability is reduced because of increased arginine disposal in combination with reduced de novo arginine synthesis. The latter is most likely caused by reduced citrulline availability. As a result, NO synthesis may be impaired, which might compromise microcirculation. These metabolic changes seem to be dependent on the severity of inflammation. Arginine or citrulline supplementation in severe inflammation might therefore be beneficial. Possibly, the use of protein-energy-enriched formulas may be a first step to improve arginine availability and NO synthesis. In critically ill children, arginine metabolism and supplementation is however a virtually unexplored field. Since pediatric sepsis is a significant health problem, which differs in epidemiology and pathophysiology from sepsis in adults, and because of the scarcity of data in this population, studies focused on pathophysiological mechanisms and possible interventions in arginine metabolism in pediatric critical illness are warranted.

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Changes in Arginine Metabolism during Sepsis and Critical Illness in Children

Betue

Deutz²

2013

Nestlé Nutrition Institute Workshop Series

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show abstract

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Op017 Arginine Appearance and No Synthesis in Critically Ill Children Can Be Increased With a Protein-Energy Enriched Enteral Formula

Cited by 1 publication

References 0 publications

Changes in Arginine Metabolism during Sepsis and Critical Illness in Children

Changes in Arginine Metabolism during Sepsis and Critical Illness in Children

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