OP111 Oral health, disability and physical function: results from studies of older people in the UK and USA

Kotronia, Eftychia; Wannamethee, GS; Papacosta, OA; Whincup, PH; Lennon, LT; Visser, Marjolein; Weyant, RJ; Harris, T.B.; Ramsay, Sheena E

doi:10.1136/jech-2019-ssmabstracts.100

Cited by 3 publications

(3 citation statements)

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“…Levels of D-dimer, the main prognostic of coagulopathy, increase naturally with age, hence the D-dimer test has a high false positive rate in elderly patients. Why D-dimer increases with age is not known but it likely reflects a higher level of vascular inflammation [46]. In cytokine storms, high levels of IL-6 cause vascular endothelial cells to secrete fibrin, which causes small clots to form in the microvasculature of the body.…”

Section: Increased Inflammation and Cytokine Storms In The Agedmentioning

confidence: 99%

Why Does COVID-19 Disproportionately Affect the Elderly?

Mueller¹,

McNamara²,

Sinclair³

2020

Preprint

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The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient’s age. Over 80% of hospitalizations are of those over 65 years of age with a 23-fold greater risk of death. In the clinic, COVID-19 patients most commonly present with fever, cough and dyspnea. Particularly in those over 65, it can progress to pneumonia, lung consolidation, cytokine release syndrome, endotheliitis, coagulopathy, multiple organ failure and death. Comorbidities such as cardiovascular disease, diabetes, obesity and hypertension increase the chances of fatal disease, but they alone do not explain the variability in COVID-19 symptoms. Here, we present the molecular differences between the young, middle-aged and elderly that may determine whether COVID-19 is a mild or life-threatening illness. We also discuss several biological age clocks that could be used in conjunction with genetic tests to identify both the mechanisms of the disease and individuals most at risk. Finally, based on these mechanisms, we discuss treatments that could increase survival in the elderly, not simply by inhibiting the virus, but by restoring patients’ ability to clear the infection.

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Section: Increased Inflammation and Cytokine Storms In The Agedmentioning

confidence: 99%

Why Does COVID-19 Disproportionately Affect the Elderly?

Mueller¹,

McNamara²,

Sinclair³

2020

Preprint

View full text Add to dashboard Cite

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“…Oral health, enabling natural eating, speaking, smiling, and socializing, plays a vital role in overall health (5,6). Deterioration of oral health can lead to various adverse health outcomes, such as cardiovascular diseases (7), cognitive impairment (8), disability (9), and all-cause mortality (10). However, studies have suggested that dental diseases could be prevented and reversed (11,12).…”

Section: Introductionmentioning

confidence: 99%

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

et al. 2022

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BackgroundLow klotho is associated with aging-related traits. However, no study has assessed the association between klotho and oral health in a large sample of population. This study aimed to explore the association between serum α-klotho and oral health in US Adults.MethodsData were from the National Health and Nutrition Examination Survey. Oral health parameters included periodontitis, self-rated oral health, and tooth loss. Logistic regression and restricted cubic spline models were adopted to evaluate the associations.ResultsA total of 6187 participants were included in the study. The median of the α-klotho level was 815.2 pg/mL. Serum α-Klotho was significantly lower in participants with poor oral health (all P <0.01). Compared with the highest tertile, the lowest tertile of α-klotho was associated with moderate/severe periodontitis, poor-rated oral health, and tooth loss, with OR (95% CI) being 1.21 (1.01, 1.48), 1.26 (1.01, 1.56) and 1.38 (1.05, 1.84), respectively. An increment of per 1 standard deviation in the α-klotho concentration was associated with lower odds of moderate/severe periodontitis (OR: 0.93; 95% CI: 0.87, 0.99). Linear dose-response relationships were found between α-klotho and the odds of moderate/severe periodontitis (P for non-linearity=0.88) and poor-rated oral health (P for non-linearity=0.66). An L-shaped dose-response relationship was found between levels of α-klotho and the odds of tooth loss (P for non-linearity=0.04).ConclusionsSerum α-klotho was associated with oral health. Further studies are necessary to clarify the potential mechanisms and demonstrate the predictive ability of klotho in oral diseases.

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“…In China, the percentage of people in China aged 60 years or over is rising dramatically [1]; persons of increasing age are more likely to suffer from various oral problems [2]. At present, though a certain proportion of oral mucosal diseases (OMD) does not need active treatment, but there is some evidence that people with oral diseases are associated with various negative outcomes, such as poor quality of life, a heavy global burden on social and economic health, high risk of disability, and impaired physical function [3,4], particular in the elderly [5,6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Oral Mucosal Diseases in Older Adults in Mainland China: A Meta-Analysis of Observational Studies

Zhou

Zhang

Yan

et al. 2020

IJERPH

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Oral mucosal disease (OMD) is a public health challenge globally, but the epidemiological findings in older adults have been inconsistent in China. Thus, this meta-analysis was carried out to explore the prevalence of OMD and its moderating factors in this population. An electronic literature search was conducted of both international (PubMed, PsycINFO, and EMBASE) and Chinese (China National Knowledge Infrastructure and WanFang) databases from inception to November 1, 2019. The Der–Simonian and Laird random effects model was used to synthesize the prevalence of OMD and its 95% confidence intervals (95% CI). Twenty-four studies covering 23,653 older adults were included. The pooled prevalence of OMD was 23% (95% confidence interval: 17.9%–29.0%) Subgroup analyses and meta-analysis revealed that the prevalence of OMD was significantly associated with the reporting sampling, year of publication, and survey (all p values <0.05). This meta-analysis found that the prevalence of OMD among older adults in mainland China was significantly high. Early detection and effective intervention of OMD in older adults have public health and clinical importance.

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OP111 Oral health, disability and physical function: results from studies of older people in the UK and USA

Cited by 3 publications

References 0 publications

Why Does COVID-19 Disproportionately Affect the Elderly?

Why Does COVID-19 Disproportionately Affect the Elderly?

Serum α-Klotho associated with oral health among a nationally representative sample of US adults

Prevalence of Oral Mucosal Diseases in Older Adults in Mainland China: A Meta-Analysis of Observational Studies

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