OP19.09: Comparison of endometrial thickness in OCP users and non OCP users

Abstract

Objective: This study was conducted to examine the histopathologic changes in tamoxifen-treated postmenopausal patients with endometrial thickness > 5 mm with transvaginal ultrasonography (TVS). Methods: Sixty two tamoxifen-treated postmenopausal breast cancer patients, receiving tamoxifen 20 mg/day for at least 1 year, underwent transvaginal pelvic ultrasonography followed by endometrial biopsy in case of an endometrial thickness > 5 mm. Ultrasonographic endometrial thickness and echotexture were recorded. Endometrial histopathologic findings were examined. Results: 55 patients were asymptomatic and 7 had abnormal bleeding. Overall, endometrial polyps were the most common histopathologic finding (42% of patients). A significant relation between ultrasonographic and histological findings was also documented (p < 0.05). A significant relation between histological findings and symptomatology was found (p < 0.05), although pathologies were also present in asymptomatic women. One endometrial cancer and three cases of hyperplasia were detected in patients with vaginal bleeding. Conclusions: Endometrial polyps are a frequent finding in tamoxifen-treated postmenopausal women with an endometrial thickness > 5 mm at transvaginal ultrasonography. Endometrial cystic atrophy may explain 'thickened endometrium' on transvaginal ultrasonography in group with no evidence of endometrial polyps, hyperplasia, or adenocarcinoma after surgical evaluation. The isolated use of TVS is insufficient for screening of endometrial hyperplasia or carcinoma in tamoxifen-treated postmenopausal women. OP19.09Comparison of endometrial thickness in OCP users and non OCP users M. Barati, F. Moramezi, N. Saadati, S. Masihi Ahvaz University of Medical Science, Islamic Republic of IranObjective: Specific cut-off levels of endometrial thickness in reproductive years women do not accurately defined. OCP suppress ovulation and endometrium is not under the effect of ovulation. In this study we tried to compare endometrial thickness in OCP users and non OCP users with transvaginal sonography. Methods: In this prospective study endometrial thickness of 83 women, 18 OCP users and 65 non OCP users were measured. These women had normal menstrual history and not having IUD. OCP users were at least in third months of OCP using and non OCP users were not using pills for at least three months. Menstrual cycle was divided to three phases, 7-10, 11-14, and 15-28 and endometrial thickness in these three phases were measured with transvaginal sonography. Results: Mean endometrial thickness in OCP and non OCP users were 2.52 and 8.97 mm respectively which had meaningful statistical difference, value < 0.001, with independent T-test and T equal to 8.18. Maximum and minimum endometrial thickness in OCP users was 4.40 and 1.00 mm respectively. Mean endometrial thickness in phase 1 to 3 in OCP users was 2.57, 2.67 and 2.68 mm and in non OCP users was 7.12, 9.04 and 10.07 mm respectively. Mean endometrial thickness in phase 1 and 3 of non OCP users had meaningful statistic...