Opacification of Hydrophilic Acrylic Intraocular Lens Attributable to Calcification: Investigation on Mechanism

Gartaganis, Sotirios P.; Kanellopoulou, Dimitra G.; Mela, Ephigenia K.; Panteli, Vassiliki S.; Koutsoukos, Petros G.

doi:10.1016/j.ajo.2008.04.032

Cited by 78 publications

(95 citation statements)

References 33 publications

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“…Nd:YAG laser treatment is ineffective in removing the calcified deposits from the lenses (1,(3)(4)(5) , as seen in most of our cases. The only effective treatment to restore vision is explantation and exchange of the calcified IOL.…”

Section: Discussionmentioning

confidence: 56%

“…Both surgical implantations were performed within 1 month by the same surgeon, using the same solutions. This may suggest that local conditions of supersaturation, either in the vicinity of the surface of the IOLs or within their substance, may promote salts development by diffusion of calcium/phosphate ions, as suggested in the study by Gartaganis et al (3) . Additionally, all cases had arterial hypertension.…”

Section: Discussionmentioning

confidence: 80%

“…Other studies have described IOL calcium deposits in patients with hypertension (3,5,8,14) . However, not all patients with IOL calcification have underlying systemic diseases (3,5,8,14) and not all cases operated for bilateral cataracts with implantation of the same IOL type have bilateral lens opacification (3) , as seen in cases 1, 2 and 5. The IOLs in each of these cases came from different lots, which might have had different susceptibilities to develop the complication.…”

Section: Discussionmentioning

confidence: 94%

“…Factors related to IOL manufacture and packaging, surgical techniques, adjuvants, as well as patient metabolic and ocular conditions, may be involved (11) . The formation of calcium deposits seems to depend both on the material of the IOL and on the local chemical microenvironment of the aqueous humor (3) . Groh et al described a possible association between IOL calcification and the metabolic disturbances in diabetes (12) .…”

Section: Discussionmentioning

confidence: 99%

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Microscopic analysis of opacification in Ioflex® hydrophilic acrylic intraocular lenses

Ventura

Lira

et al. 2012

Rev. bras.oftalmol.

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Five cases of intraocular lens (IOL) opacification in patients implanted with the Mediphacos Ioflex® IOL are described. Clinical data in each case was obtained from the patient's medical record. The five explanted IOLs underwent gross and light microscopic analysis. Selected lenses were processed for further evaluation and multiple sagittal cuts were stained with the alizarin red and von Kossa methods. Light microscope analysis confirmed the presence of deposits on and within the lens, which stained positive for calcium. The reason why calcification has occurred in these cases remains unclear, but surgeons should be aware of this potential late postoperative complication.Keywords: Lenses, intraocular; Lens implantation, intraocular; Reoperation; Device removal; Microscopy; Case reports RESUMO Cinco casos de opacificação de lente intraocular (LIO) em pacientes implantados com a LIO Ioflex® da Mediphacos são descritos. Os dados clínicos dos pacientes foram obtidos a partir dos prontuários médicos. As cinco LIOs explantadas foram enviadas para análise macroscópica e sob microscopia óptica. Algumas lentes foram processadas para análise adicional e múltiplos cortes sagitais foram corados pelos métodos de vermelho de alizarina e von Kossa. A análise sob microscopia óptica confirmou a presença de depósitos na superfície e no corpo da lente, que coraram positivamente para cálcio. A razão pela qual a calcificação ocorreu nestes casos permanece obscura. Entretanto, cirurgiões devem estar atentos para esta potencial complicação tardia.Descritores: Lentes intraoculares; Implante de lenteintraocular; Reoperação; Remoção de dispositivo; Microscopia; Relatos de casos 1 Fundação Altino Ventura -FAV -Recife (PE), Brazil;

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Microscopic analysis of opacification in Ioflex® hydrophilic acrylic intraocular lenses

Ventura

Lira

et al. 2012

Rev. bras.oftalmol.

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“…The formation of calcium deposits appears to depend both on the material of the IOL and on the local chemical microenvironment of the aqueous humor (12) . The Oft Cryl® IOL is composed of a poly-hydroxyethylmethacrylate copolymer.…”

Section: Discussionmentioning

confidence: 99%

Microscopic analysis of an opacified OFT CRYL® hydrophilic acrylic intraocular lens

Ventura¹,

MacLean²,

Lira³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Spoke-Wheel–Shaped Deposits Over Intraocular Lens

Jain

Kekunnaya

2022

JAMA Ophthalmol

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A 13-year-old healthy child had a history of penetrating trauma with a broomstick at the age of 6 years for which she underwent an uneventful pars plana vitrectomy and lens aspiration with posterior capsulotomy. A hydrophilic acrylic intraocular lens (IOL) (+21.00 diopter, Model-SQRYCF; Caregroup Sight Solution) was implanted. The IOL showed multiple spokelike deposits over the anterior and posterior surface 10 months after implantation (Figure). These deposits did not obscure the visual axis and remained stable on follow-up. The bestcorrected visual acuity was 20/30, and N6 for near, associated with a nasal retinal fold arising from the disc. The IOL deposits seen have been described as composed of calcium and phosphorus. [1][2][3] Nd:YAG posteriorcapsulotomyhasnotbeennotedtohelpclearthedeposits. 4,5 The IOL might be explanted and exchanged with a newer hydrophobic acrylic lens if severe deterioration of vision is noted. 6

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Opacification of Hydrophilic Acrylic Intraocular Lens Attributable to Calcification: Investigation on Mechanism

Cited by 78 publications

References 33 publications

Microscopic analysis of opacification in Ioflex® hydrophilic acrylic intraocular lenses

Microscopic analysis of opacification in Ioflex® hydrophilic acrylic intraocular lenses

Microscopic analysis of an opacified OFT CRYL® hydrophilic acrylic intraocular lens

Spoke-Wheel–Shaped Deposits Over Intraocular Lens

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