Open Access: Plasticity of pheromone-mediated avoidance behavior in C. elegans

Social and sexual behaviors in C. elegans: the first fifty years

“…Ascarosides can have multiple behavioral effects on worms, inducing aggregation, attraction/retention, aversion, and promotion of foraging, depending on their chemical structures, concentrations, and interactions; moreover, the response of the receiver depends on its sex, stage, previous experience, genetic background, and other factors (Aprison and Ruvinsky, 2019;Borne et al, 2017;Dong et al, 2016;Fagan et al, 2018;Greene et al, 2016;Hong et al, 2017;Izrayelit et al, 2012;Jang et al, 2012;Lee et al, 2019;Macosko et al, 2009;Pungaliya et al, 2009;Ryu et al, 2018;Scott et al, 2017;Sims et al, 2016;Srinivasan et al, 2008;Srinivasan et al, 2012;von Reuss et al, 2012;. (Plasticity in the aversive responses to ascarosides is the subject of another review in this issue (Cheon et al, 2020).) Furthermore, exposure to ascarosides modulates other worm sensory behaviors (Wu et al, 2019;Yamada et al, 2010;Yoshimizu et al, 2018) and can also cause physiological changes, including altered germline proliferation and germ cell function, increased stress resistance and lifespan, and changes in lipid metabolism Ruvinsky, 2015, 2016;Hussey et al, 2017;McKnight et al, 2014).…”