Open and Minimal Approaches to Pancreatic Adenocarcinoma

Abstract

Surgical options and approaches to pancreatic cancer are changing in the current era. Neoadjuvant treatment strategies for pancreatic cancer combined with the increased use of minimal access surgical techniques mean that the modern pancreatic surgeon requires mastering a number of surgical approaches with to optimally manage patients. Whilst traditional open surgery remains the most frequent approach for surgery, the specific steps during surgery may need to be modified in light of the aforementioned neoadjuvant treatments. Robotic and laparoscopic approaches to pancreatic resection are feasible, but these surgical methods remain in their infancy. In this review article, we summarise the current surgical approaches to pancreatic cancer and how these are adapted to the minimal access setting with discussion of the patient outcome data.

Prognostic association between NLRP3 inflammasome expression level and operable pancreatic adenocarcinoma

“…[1][2][3] Surgical resection is potentially considered as an only curative treatment approach for patients with pancreatic adenocarcinoma. 4,5 However, when diagnosed with pancreatic adenocarcinoma, only 15%-20% of patients had a chance of undergoing curative surgery, and those who received curative resection had a postoperative 5-year survival rate of less than 20%. 6,7 Recently, a large number of clinical and experimental studies focused on the prognosis analysis of pancreatic cancer and introduced various clinical and pathological prognostic indictors.…”