Open comparative trial of formestane versus megestrol acetate in postmenopausal patients with advanced breast cancer previously treated with tamoxifen

Freue, M.; Kjær, Mogens; Boni, C.; Joliver, J.; Jänicke, F.; Willemse, H.B.; Coombes, R. Charles; Belle, Simon Van; Perez-Carrion, R.; Zieschang, J.; Palacios, Patricia; Rose, Carsten

doi:10.1054/brst.1999.0118

Cited by 11 publications

(1 citation statement)

References 18 publications

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“…Median survival was significantly longer in the former group. Freue (19) compared the steroidal AI formestane with MA as second‐line treatment and reported no significant differences in terms of ORR and TTP but reported that formestane, despite being given by intramuscular injection every 2 weeks, was better tolerated than MA. Rose et al (20) carried out a trial directly comparing letrozole and anastrozole as second‐line therapy.…”

Section: Clinical Usesmentioning

confidence: 99%

Aromatase inhibitors and breast cancer: time for a change?

Fentiman

2004

International Journal of Clinical Practice

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Aromatase inhibitors bind reversibly or irreversibly to the aromatase enzyme in peripheral fat and also in the breast, leading to undetectable plasma levels of oestrogens in postmenopausal women. These agents have been shown to be more effective than tamoxifen in first-line treatment of oestrogen receptor-positive advanced and metastatic breast cancer. Additionally, they have been demonstrated to be superior as both adjuvant and neoadjuvant treatment. It is likely that they will also be useful for breast cancer prevention but the cost/benefit ratio has yet to be determined.

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Section: Clinical Usesmentioning

confidence: 99%

Aromatase inhibitors and breast cancer: time for a change?

Fentiman

2004

International Journal of Clinical Practice

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Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women

Gibson

Lawrence

Dawson

et al. 2009

Cochrane Database of Systematic Reviews

134

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Endocrine Therapy for Hormone Receptor‐Positive Breast Cancer

Buzdar,

Dawood,

Harvey

et al. 2017

Holland‐Frei Cancer Medicine

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Overview The importance of the reproductive endocrine system in breast cancer treatment began to be appreciated at the turn of nineteenth century. It was around this time that it was realized that approximately one‐third of premenopausal women with advanced breast cancer would respond to oophorectomy. However, it was only when the estrogen receptor (ER) was discovered that it was possible to fully appreciate the mechanisms underlying the activity of ovarian ablation and other associated treatments for breast cancer such as ovarian irradiation, adrenalectomy, and hypophysectomy. Research into both the estrogen and progesterone pathways not only provided a deeper understanding of the underlying mechanism of the carcinogenic pathway involved in the development of breast cancer but also allowed identification of potential targets for therapeutic intervention. This chapter discusses recent advances in the molecular biology and physiology underlying the estrogen and progesterone receptor (PR) pathways and potential targets for intervention. In addition it examines and compares the pharmacology and efficacy of the different endocrine agents used in the management of both early and advanced stage breast cancer.

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Open comparative trial of formestane versus megestrol acetate in postmenopausal patients with advanced breast cancer previously treated with tamoxifen

Cited by 11 publications

References 18 publications

Aromatase inhibitors and breast cancer: time for a change?

Aromatase inhibitors and breast cancer: time for a change?

Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women

Endocrine Therapy for Hormone Receptor‐Positive Breast Cancer

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