Open evaluation of amlodipine in the monotherapeutic treatment of mild to moderate hypertension in nigerian patients

Isah, Ambrose O.; Obasohan, A. O.; Okpako, L.O.

doi:10.1016/s0011-393x(05)80052-9

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…This was observed early following the introduction of the CCBs. [ 31 32 ] This finding need to be further investigated as it was also seen using the MedDRA[ 18 ] system organ classification that the renal and urinary disorders had the highest frequency. We equally note the development of dizziness and dryness of legs to alpha blockers, (though infrequently used in this study) two of the users (22%) had adverse reactions, the reactions observed may be related to the orthostatic hypotensive effect of alpha blockers.…”

Section: Discussionmentioning

confidence: 99%

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

Olowofela

Isah

2017

Ann Afr Med

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Background:There has been a dearth of comprehensive data on the profile of adverse reactions to antihypertensive medicines in the Nigerian setting despite increased use.Objective:This study was aimed to characterize the adverse reactions experienced in the homogenously black African population.Methods:The study was carried out at the University of Benin Teaching Hospital, Benin City, Nigeria, in consenting eligible hypertensive patients ≥18 years. Adverse reactions were sought using patient's self-report and a medicine-induced symptom checklist.Results:A total of 514 patients (340 females) aged 22–97 years were studied. Thirteen percent, 27.6%, 26.7%, 22.0%, and 10.7% were on 1, 2, 3, 4, and ≥5 medicines, respectively, for control of their blood pressure with the frequency of adverse effects increasing proportionately up to four medicines. Adverse reactions to antihypertensive medicines were reported by a total of 93 (18.1%) patients. Diuretics – 27.9%, calcium channel blockers (CCBs) – 26.8%, and angiotensin-converting enzyme inhibitors (ACEIs) – 26.8% accounted for most of the adverse reactions seen, notably frequent micturition and headaches (CCB); excessive micturition and dizziness (diuretics); dry irritating cough (ACEI). Notable complaints for all patients using the checklist were increased frequency of micturition, reduction in libido, and headaches. The reactions resulted in the discontinuation and substitution of therapy in 49.5% of the patients.Conclusions:The characterization of these reactions in Nigerians requires further studies as frequent micturition reported is still a neglected complaint in antihypertensive therapy.

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Section: Discussionmentioning

confidence: 99%

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

Olowofela

Isah

2017

Ann Afr Med

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“…In the light of the above and given the attenuated response of black hypertensive patients to angiotensin converting enzyme inhibitors (ACEIs), angiotensin AT 1 receptor blockers (ARBs) and beta-blockers (BBs) [13,27,28,29], the use of AML and HCZ as first-line or combination treatment of essential hypertension has become a popular option in Nigeria [29]. This is because apart from their effectiveness in specifically addressing the low renin, salt-sensitive and volume-dependent hypertension that is characteristic of this population, these drugs are also comparatively cheap, available and tolerable [31,32].…”

Section: Introductionmentioning

confidence: 99%

Effects of Amlodipine and Hydrochlorothiazide Combination Therapy on Lipid Profiles in Hypertensive Nigerians

Iyalomhe¹,

Omogbai²,

Iyalomhe³

2013

AJPS

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There is paucity of information regarding the effects of combination therapy with amlodipine and hydrochlorothiazide on lipid profiles in hypertensive Nigerians. Therefore, to evaluate whether this combination therapy would ameliorate or aggravate the known metabolic adversity of hydrochlorothiazide on lipid parameters, 90 male and female Nigerians aged 31-86 years with newly diagnosed uncomplicated essential hypertension (blood pressure > 160/90 ≤ 180/120mmHg) were enrolled into a randomised 48-week study. Treatment was initiated in the patients, who were 30 each in amlodipine, hydrochlorothiazide and amlodipine-hydrochlorothiazide groups, with amlodipine 5mg, hydrochlorothiazide 25mg and amlodipine 5mg + hydrochlorothiazide 25mg, respectively. Body mass index, blood pressure and lipid profiles were evaluated at baseline as well as at the end of weeks 1, 3, 6, 12, 24, 36 and 48. The 3 regimens significantly (p<0.05) reduced blood pressure. At the end of week 48, mean male/female % significant decrease or increase in lipid parameters in amlodipine, hydrochlorothiazide and amlodipine-hydrochlorothiazide groups were, respectively:-4.3/-1.5, 2.8/3.7 and 2.6/2.5, p<0.0001 for total cholesterol;-7.2/-2.6, 5.3/5.6 and 6.6/6.2, p<0.0001 for triglyceride; 16.5/19.6,-12.0/-8.6 and-7.8/-8.4, p<0.0001 for high density lipoprotein cholesterol;-4.6/-3.0, 5.6/11.7 and 4.5/8.0, p<0.0001 for low density lipoprotein cholesterol. This study demonstrates that beyond reducing blood pressure, amlodipine and hydrochlorothiazide combination therapy has varied effects on lipid panel and it also suggests that, with regard to cardiovascular risk profile, it may be preferable to initiate treatment with a regimen of amlodipine to which hydrochlorothiazide is subsequently added, instead of a regimen of hydrochlorothiazide to which amlodipine is later added or a regimen of ab initio amlodipinehydrochlorothiazide combination therapy.

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“…In Nigeria, calcium channel blockers (CCBs) such as AML and thiazides such as hydrochlorothiazide (HCZ) are popular antihypertensive agents for combination therapy. This is because apart from their effectiveness in specifically addressing the low renin, salt-sensitive and volume dependent hypertension [3][4]16] that is prevalent among the people, these drugs are comparatively cheap, available and tolerable [17][18][19][20]. However, many authors [17,[21][22][23] have expressed safety concerns over increasing evidence of adverse effects including electrolyte derangement, such as hyponatraemia, disproportionate hypochloraemia, alkalosis and hypokalaemia produced during diuretic therapy.…”

Section: Introductionmentioning

confidence: 99%

Serum and Urine Electrolyte Profiles during Amlodipine and Hydrochlorothiazide Combination Therapy in Nigerian Patients with Essential Hypertension

Iyalomhe¹,

Omogbai²,

Iyalomhe³

et al. 2013

BJMMR

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Aims: To evaluate changes in electrolyte profiles during combination treatment with amlodipine (AML) and hydrochlorothiazide (HCZ) in hypertensive Nigerians. Study Design: Randomized, open-label, prospective, two-centre, outpatient, 48-week study. Methodology: We enrolled 90 male and female Nigerians aged 31-86 years with uncomplicated essential hypertension (blood pressure [BP] > 160/90 ≤ 180/120mmHg). Patients, who were 30 each (15males [M] and 15females [F]) in AML, HCZ and AML-HCZ groups, were treated, respectively, with 5mg AML for 6 weeks (wks) and the dose increased to 10mg till wk 12 (monotherapy) after which HCZ 25mg was added; HCZ 25mg till wk 6 (monotherapy) after which AML 5-10mg was added; and AML 5-10mg +

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Open evaluation of amlodipine in the monotherapeutic treatment of mild to moderate hypertension in nigerian patients

Cited by 5 publications

References 16 publications

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

Effects of Amlodipine and Hydrochlorothiazide Combination Therapy on Lipid Profiles in Hypertensive Nigerians

Serum and Urine Electrolyte Profiles during Amlodipine and Hydrochlorothiazide Combination Therapy in Nigerian Patients with Essential Hypertension

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