Open-label Crossover Study of Vitamin A Ointment as a Treatment for Keratoconjunctivitis Sicca

Evaluation of Retinoic Acid Ophthalmic Emulsion in Dry Eye

“…However, that study had no placebo control group and used a different vehicle for retinoic acid. Our symtomatic findings confirm two earlier studies (12,13) which found no difference in symptoms (foreign body sensation, burning, dryness and photophobia) between the placebo (petrolatum, mineral oil) and 0.01% retinoic acid in Keratoconjunctivitis sicca (KCS) and non-KCS patients.…”

Beneficial effect of sodium sucrose‐sulfate on the ocular surface of patients with severe KCS in primary Sjögren's syndrome

“…Only a few attempts have successfully been directed against an active repair of the epithelium and at the same time supplementing the aqueous deficit. The topical use of retinoic acid has shown some promising results (Tseng et al 1985;Gilbard et al 1989), and so has the use of protease inhibitors (Prause 1984), the latter has recently gained increasing interest (Salonen et al 1987;Cejkova et al 1989). …”

Serum eye drops, amniotic membrane and limbal epithelial stem cells—tools in the treatment of ocular surface disease

“…Attempts to develop a biological tear substitute that has lubricating, and nutrient properties promoting ocular surface renewal and immunological defence have been limited. Isolated reports of single compound topical agents such as Vitamin A (Gilbard et al 1989), EGF (Elliott 1980) and albumin (Shimmura et al 2003) have show some in vitro and in vivo efficacy, but long-term clinical applications have not been developed. Newer lubricants such as those containing carboxymethylcellulose, boast improved ocular surface retention and epithelial proliferation, whereas sodium hyaluronate preparations exploit the property that it is a ubiquitous naturally occurring extracellular matrix glycosaminoglycan, which plays an important role in wound healing, inflammation and lubrication.…”