Open-label placebo reduces fatigue in cancer survivors: a randomized trial

Zhou, Eric S.; Hall, Kathryn T.; Michaud, Alexis L.; Blackmon, Jaime E.; Partridge, Ann H.; Recklitis, Christopher J.

doi:10.1007/s00520-018-4477-6

Cited by 55 publications

(55 citation statements)

References 40 publications

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“…Three smaller pilot or feasibility clinical studies of open label placebo—two in people with allergic rhinitis (n=25, n=45)1011 and one in depression (n=20)12—also suggest potential benefits. In addition, two independent studies in chronic low back pain (n=127) and cancer related fatigue (n=40) recently reported significant positive results 1314…”

Section: Open Label Placebo Studiesmentioning

confidence: 99%

Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?

Kaptchuk

Miller

2018

BMJ

112

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Section: Open Label Placebo Studiesmentioning

confidence: 99%

Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?

Kaptchuk

Miller

2018

BMJ

112

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“…Sie stellen aber insgesamt einen beeindruckenden ersten Wirknachweis für den klinischen Nutzen von Open-label Placebos dar. Die Ergebnisse weisen auf eine signifikante Reduktion der Symptomlast bei Schmerzerkrankungen (episodische Migräne [22] chronischer Rückenschmerz [27,28], Reizdarmsyndrom [29]), neuropsychiatrischen Syndromen (chronisches Fatigue-Syndrom bei Tumorerkrankungen [30], Aufmerksamkeitsdefizit-Hyperaktivitäts-Syndrom [31], Depression [32]) und bei allergischer Rhinitis [33] hin. Die beobachteten Effektgrößen sind dabei vergleichbar mit denen, die im Rahmen traditioneller Placebo-Anwendungen belegt sind.…”

Section: Open-label Placebosunclassified

Der Placeboeffekt in der Schmerztherapie – für den klinischen Alltag nutzbar? Ja, unbedingt!

Kleine-Borgmann¹,

Bingel²

2020

Aktuelle Rheumatologie

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ZusammenfassungAls Placeboeffekte bezeichnet man positive physiologische oder psychologische Veränderungen, die nach einer Einnahme von Medikamenten ohne spezifischen Wirkstoff oder Scheineingriffen auftreten und durch Erwartungs- und Konditionierungsprozesse induziert werden. Die mit Placeboeffekten einhergehenden neurobiologischen und peripher-physiologischen Vorgänge können auch bei der Vergabe von wirkstoffhaltigen Medikamenten eine wichtige Rolle spielen und sind somit nicht zwingend an die Gabe eines Scheinmedikamentes gebunden. Die Darreichung von „traditionellen“ Placebos ist im klinischen Alltag aus juristischen und ethischen Gründen höchst problematisch. Dieser Beitrag zeigt neben neuen Erkenntnissen zu offenen Placebo-Anwendungen (Open-Label Placebos) Wege auf, wie die zugrundeliegenden Mechanismen von Placeboantworten dennoch gezielt im schmerztherapeutischen Alltag genutzt werden können, um die Wirksamkeit, Verträglichkeit und Compliance bestehender pharmakologischer und anderer Therapien zum Wohle des Patienten zu optimieren.

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“…25,31,32 Over a dozen clinical trials of OLPs have been undertaken for a range of conditions including IBS, 31 chronic lower back pain, 33 episodic migraine 34 and cancer-related fatigue. 35,36 In many of these experiments, investigators appear to strive to optimise placebo effects via positive framing in disclosures; for example, in seven out of 13 OLP trials, clinician-experimenters informed participants of four discussion points related to placebos: 31,33,[35][36][37][38][39] 1. The placebo effect is powerful.…”

Section: Questioning the Orthodoxy: Open-label Placebosmentioning

confidence: 99%

“…32 Clinical trials into OLPs show promise for a range of self-reported conditions including irritable bowel syndrome, chronic lower back pain, episodic migraine and cancerrelated fatigue. 31,[33][34][35][36][37][38][39] Studies have been small and of short duration, and it is currently unclear whether the action of taking the pills, the rationale provided to participants and/or the quality of interaction influences the size of placebo effects in these studies. [40][41][42] In addition, the effects of OLP prescription on patient behaviour and help-seeking remain unknown.…”

Section: A Third Way? Open-label Placebos and Practitioner Behaviourmentioning

confidence: 99%

The role of placebos in family medicine: Implications of evidence and ethics for general practitioners

Blease¹

2019

Aust J Gen Pract

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Charlotte R Blease Background Placebo use is prevalent in primary care. A wealth of discourse on the ethical use of placebos in clinical contexts invariably assumes that placebos oblige practitioners to peddle in deception. However, the recent surge in empirical findings within the field of 'placebo studies' provides a very different perspective: namely, that placebos may yet prove to be both effective and ethical. Objective The aim of this article is to synthesise state-of-the-art scientific and bioethical research to provide up-to-date recommendations on placebo use for general practitioners. Discussion After disambiguating placebo concepts, this article outlines experimental studies into placebo effects and explores the ethical and evidence-based arguments for prescribing placebos. Evaluating the latest research into 'open-label placebos', it can be surmised that there are not yet persuasive grounds to incorporate these treatments into routine clinical care. Notwithstanding, the quality of physician interactions may go some way to harnessing remedial placebo effects among patients.

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Open-label placebo reduces fatigue in cancer survivors: a randomized trial

Cited by 55 publications

References 40 publications

Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?

Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?

Der Placeboeffekt in der Schmerztherapie – für den klinischen Alltag nutzbar? Ja, unbedingt!

The role of placebos in family medicine: Implications of evidence and ethics for general practitioners

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