Open lung biopsy of patients with rheumatoid arthritis

Hakala, M; Pääkkö, Paavo; Huhti, E; Tarkka, Matti; Sutinen, S

doi:10.1007/bf02030506

Cited by 67 publications

(29 citation statements)

References 27 publications

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“…To evaluate IP activity, open lung biopsy [6,13,28], Ga-67 scintigram [13], and BAL [4,13,24] are considered reliable examinations. However, it is practically impossible to apply these examinations repeatedly because of their side effects.…”

Section: Discussionmentioning

confidence: 99%

Detection of Interstitial Pneumonitis in Patients with Rheumatoid Arthritis by Measuring Circulating Levels of KL-6, a Human MUC1 Mucin

Oyama

Kohno

Yokoyama

et al. 1997

Lung

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In rheumatoid arthritis (RA), interstitial-pneumonitis is one of the major extraarticular complications that worsens a patient's prognosis. KL-6, a human MUC1 mucin, has been reported to be a sensitive serum marker for activity of interstitial pneumonitis. We investigated the clinical significance of serum KL-6 level in patients with RA. Serum levels of KL-6 and RA-associated inflammatory markers were evaluated in 177 RA patients. The diagnosis of active interstitial pneumonitis was made by clinical symptoms, pulmonary function tests, chest X-ray film, and high resolution CT. Serum KL-6 was increased in 8 of 9 (88.9%) RA patients with active interstitial pneumonitis but in only 1 of 168 (0.6%) RA patients without active interstitial pneumonitis. No significant correlation was found between KL-6 level and conventional clinical parameters. In RA, abnormal elevation of serum KL-6 strongly indicates the complication of active interstitial pneumonitis.

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Section: Discussionmentioning

confidence: 99%

Detection of Interstitial Pneumonitis in Patients with Rheumatoid Arthritis by Measuring Circulating Levels of KL-6, a Human MUC1 Mucin

Oyama

Kohno

Yokoyama

et al. 1997

Lung

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“…Several studies of patients with RA-ILD have suggested a relationship of the UIP pattern to survival [20,[28][29][30]. YOUSEM et al [28] described 40 patients with RA-ILD, five of whom had a UIP pattern on surgical lung biopsy.…”

Section: Uip Pattern and Survivalmentioning

confidence: 99%

“…Four of the UIP-pattern patients died during follow-up, whereas only one of the non-UIP-pattern patients died. HAKALA et al [29] reported on 24 patients with RA-ILD. Two patients died; both had honeycombing present on surgical biopsy.…”

Section: Uip Pattern and Survivalmentioning

confidence: 99%

Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease

Kim¹,

Elicker²,

Maldonado³

et al. 2009

Eur Respir J

505

380

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“…The clinical outcome of CTD-OP has not been well defined, even though various studies have reported a worse prognosis, a lower complete recovery rate, and a tendency towards higher recurrence rates as compared to the idiopathic form [121,123]. In RA, OP represents up to 10-15% of any ILD involvement and is often observed during the follow-up of joint-associated symptoms, but in rare cases it can predate the development of joint manifestations or serological conversion, which may lead to underdiagnosis and missing of the link between OP and underlying but early and undiagnosed RA [123,125,126,127]. In DM-PM, OP is an even more common manifestation, with its reported prevalence approaching 20% [125,128,129].…”

Section: Op and Afopmentioning

confidence: 99%

Acute Respiratory Events in Connective Tissue Disorders

Papiris¹,

Manali²,

Kolilekas³

et al. 2016

Respiration

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Subacute-acute, hyperacute, or even catastrophic and fulminant respiratory events occur in almost all classic connective tissue disorders (CTDs); they may share systemic life-threatening manifestations, may precipitously lead to respiratory failure requiring ventilatory support as well as a combination of specific therapeutic measures, and in most affected patients constitute the devastating end-of-life event. In CTDs, acute respiratory events may be related to any respiratory compartment including the airways, lung parenchyma, alveolar capillaries, lung vessels, pleura, and ventilatory muscles. Acute respiratory events may also precipitate disease-specific extrapulmonary organ involvement such as aspiration pneumonia and lead to digestive tract involvement and heart-related respiratory events. Finally, antirheumatic drug-related acute respiratory toxicity as well as lung infections related to the rheumatic disease and/or to immunosuppression complete the spectrum of acute respiratory events. Overall, in CTDs the lungs significantly contribute to morbidity and mortality, since they constitute a common site of disease involvement; a major site of infections related to the ‘mater' disease; a major site of drug-related toxicity, and a common site of treatment-related infectious complications. The extreme spectrum of the abovementioned events, as well as the ‘vicious' coexistence of most of the aforementioned manifestations, requires skills, specific diagnostic and therapeutic means, and most of all a multidisciplinary approach of adequately prepared and expert scientists. Avoiding lung disease might represent a major concern for future advancements in the treatment of autoimmune disorders.

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Open lung biopsy of patients with rheumatoid arthritis

Cited by 67 publications

References 27 publications

Detection of Interstitial Pneumonitis in Patients with Rheumatoid Arthritis by Measuring Circulating Levels of KL-6, a Human MUC1 Mucin

Detection of Interstitial Pneumonitis in Patients with Rheumatoid Arthritis by Measuring Circulating Levels of KL-6, a Human MUC1 Mucin

Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease

Acute Respiratory Events in Connective Tissue Disorders

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