Open reduction and internal fixation of delayed intracapsular comminuted condylar fracture of mandible with preoperative computer-aided design

Zhang, B.; Yang, Mingyong; Zhou, Qing; Liu, Q.

doi:10.1016/j.ijom.2015.08.406

Cited by 1 publication

(2 citation statements)

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“…However, due to the use of antibiotics, most studies have shown no significant difference among these clinical indicators in infected and non-infected patients. Nevertheless, some studies have shown a significant difference in C-reactive protein level between infected patients and non-infected patients ( 17 , 20 ). Therefore, in this study, we investigated the relationship between C-reactive protein and postoperative infection to predict the timing of secondary surgery for open fractures.…”

Section: Discussionmentioning

confidence: 99%

“…However, due to the application of antibiotics after the first surgery, the differences in clinical indicators such as erythrocyte sedimentation rate (ESR), white blood cell and neutrophil count and other indexes between infected and non-infected patients are not noticeable. Prior studies have shown that the C-reactive protein levels are significantly different between these two groups of patients ( 17 ). So, this study aimed to find a surgical index that can accurately determine the timing of secondary surgery in order to promote early rehabilitation.…”

Section: Introductionmentioning

confidence: 91%

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Factors related to infection after fixation in the process of late healed bone fracture

Zhang

Zhan

Zou

et al. 2017

Experimental and Therapeutic Medicine

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We studied the factors related to infection after fixation in the process of bone late healed fracture and explored the factors that could predict the risk of postoperative infection. A total of 100 patients with open fractures of the tibia and fibula diagnosed in Zhengzhou No. 7 People's Hospital from 2007 to 2016 were enrolled in this study. Patients were subjected to staging surgery treatment. We divided them into the infection group (n=52) and the non-infection group (n=48) according to whether or not infection occurred after operation. Pearson correlation was used to analyze the relationship between postoperative infection and preoperative factors, and ROC curve was used to explore the factors which could predict the risk of postoperative infection. As a result, surgical timing and C-reactive protein were correlated with postoperative infection (P<0.05), and surgical timing was negatively correlated with postoperative infection. C-reactive protein was positively correlated with postoperative infection. Using 7 days as the cut-off point of surgical timing, false positive and false negative rates were 0 and 27.7%, respectively. Youden index value was 72.3%, and positive predictive and negative predictive values were 42.5 and 100%, respectively. With 54.55 mg/l as the cut-off point of C-reactive protein, the sensitivity and specificity of prediction were 88.2 and 94.1%, while the false negative and false positive rates were 11.8 and 5.9%, respectively. The Youden index value was 82.3%, and the positive predictive and negative predictive values were 75 and 96.7%, respectively. With 7 days as the cut-off point of surgical timing and 54.55 mg/l as the cutoff point of C-reactive protein at the same time, the positive predictive and negative predictive values were 88.2 and 97.6%, respectively. The false negative and false positive rates were 11.8 and 2.4%, respectively. The Youden index value was 85.8%. The positive predictive and negative predictive values were 88.2 and 97.6%, respectively. In conclusion, surgical timing and C-reactive protein were strongly correlated with postoperative infection and this correlation was not affected by age, sex or other inflammatory indexes. The incidence of postoperative infection was reduced when both factors were applied for the determination of surgery. In addition, incidence of complications will be reduced and the cure rate improved.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%