Open rhinoplasty for treatment of nasal tip haemangioma

Amer, Tarek A.; Elwakil, Tarek F.; Elbasiouny, Mahmoud S.

doi:10.1007/s00238-007-0152-8

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…The use of FPDL is still strongly recommended at the earliest sign of haemangiomas. Treatment is repeated at 4-to 6-weekly intervals until the inhibition of further growth and/or the induction of regression of the proliferating haemangiomas, with no further improvement being achieved (Ethunandan and Mellor 2006;Amer et al 2007). The same protocol and objectives of the treatment have been employed in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Cyclin D1 gene amplification in proliferating haemangioma

et al. 2009

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Cyclin D1 gene amplification has been reported to promote abnormal endothelial cell proliferation and angiogenesis; these findings constantly present in proliferating haemangiomas. The present study was conducted to evaluate cyclin D1 gene amplification by fluorescence in situ hybridization analysis in tissue biopsies of 22 proliferating haemangiomas from 20 infants. Two significant correlations of cyclin D1 gene amplification with the early onset and the duplication of proliferating haemangiomas have been observed. Moreover, a significant correlation (P< or =0.05) has been found between the treatment parameters of proliferating haemangiomas with the amplified versus the normal cyclin D1 gene. Proliferating haemangiomas with the amplified cyclin D1 gene required more frequent flashlamp pulsed dye laser treatment sessions at the maximum dosimetry and more frequent intralesional steroid injections at the maximum dose/injection but treatment outcomes were limited. The more frequent post-treatment complications among proliferating haemangiomas with cyclin D1 gene amplification might be attributable not only to the associated more aggressive natural course, but also to the higher treatment parameters needed for effective treatment. Within the limitations of the present study, cyclin D1 gene amplification was seen for the first time in proliferating haemangiomas. We have found that the amplification of the cyclin D1 gene can predict the more aggressive natural course of proliferating haemangiomas and the limited outcome and higher incidence of complications after non-excision treatment modalities. The present findings reflect the possible usefulness of antisense cyclin D1 to improve the therapeutic outcome of proliferating haemangiomas.

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Section: Discussionmentioning

confidence: 99%

“…Deep haemangiomas originating from the reticular dermis or subcutaneous tissues appear as bluish or relatively colourless masses. On occasion, both components can be present simultaneously resulting in what is called mixed or compound haemangiomas (Amer et al 2007;Ethunandan and Mellor 2006). Table 1 summarizes patient and haemangioma data.…”

Section: Methodsmentioning

confidence: 99%

Cyclin D1 gene amplification in proliferating haemangioma

et al. 2009

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“…However, the unpredictable outcome and the possible serious complications after proliferation and proposed involution, in addition to the consequences of cosmetic disfigurement associated with the psychologic trauma first in parents and later in the affected children, all alleviate for prompt treatment of IH [6]. Standard treatment options for IH include corticosteroids, laser surgery, cryosurgery, interferon, and vincristine [13][14][15]. Each of these treatment options has its restrictions and/or side effects [16].…”

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confidence: 99%

Propranolol treatment of infantile hemangioma: clinical and radiologic evaluations

Talaat

Elbasiouny

Elgendy

et al. 2012

Journal of Pediatric Surgery

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“…Amer et al 35 recommend a nonsurgical treatment with a laser or an intralesional corticosteroid injection in three to four steps until the end of the 2nd year of life after diagnosing a hemangioma.…”

Section: Surgical Treatment Of Nasal Hemangioma and Vascular Deformitmentioning

confidence: 99%

Nasal Reconstruction in Children

2014

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The nose represents the center of the face. The nasal shape changes with the progression from infancy to adulthood. In newborns, the main supporting structure of the nose is the dorsal septal cartilage; it is the facial growth center. The loss of septal cartilage at different ages leads to various facial syndromes involving the nose, maxilla, and orbita. Therefore, every surgical treatment can compromise not only the nasal growth but also the growth of the whole face. Childhood trauma or a malformation of the nose can also cause enormous functional impairments similar to those caused by surgical treatments. Our contribution represents different aspects of nasal deformities and their treatment. An individual concept is indispensable to reach the best compromise in all cases. The postulate of an early treatment gives priority to physical and mental damage control. The late therapy concept uses the inimitable potential of the growth of different tissues needed for a septoplasty and should be protected from iatrogenic impairment. We recommend a first-line pediatric nasal reconstruction, an attentive follow-up, and finally, a secondary nasal reconstruction in the adult patient if required for achieving normalcy.

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Open rhinoplasty for treatment of nasal tip haemangioma

Cited by 6 publications

References 19 publications

Cyclin D1 gene amplification in proliferating haemangioma

Cyclin D1 gene amplification in proliferating haemangioma

Propranolol treatment of infantile hemangioma: clinical and radiologic evaluations

Nasal Reconstruction in Children

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