Opening a New Lipid “Apo-thecary”: Incorporating Apolipoproteins as Potential Risk Factors and Treatment Targets to Reduce Cardiovascular Risk

Jacobson, Terry A.

doi:10.4065/mcp.2011.0128

Cited by 33 publications

(38 citation statements)

References 127 publications

(165 reference statements)

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“…However, according to at least one US Expert Panel the incremental expense is warranted in certain patients (5 ). The therapeutic value relative to the incremental cost of each of the measurements is currently under aggressive debate (5,56 ).…”

Section: Comparison Of Apo B Ita/ina and Ldl-p Methodsmentioning

confidence: 99%

Association of Apolipoprotein B and Nuclear Magnetic Resonance Spectroscopy–Derived LDL Particle Number with Outcomes in 25 Clinical Studies: Assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices

Cole¹,

Contois²,

Csákó

et al. 2013

Clinical Chemistry

115

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BACKGROUND:The number of circulating LDL particles is a strong indicator of future cardiovascular disease (CVD) events, even superior to the concentration of LDL cholesterol. Atherogenic (primarily LDL) particle number is typically determined either directly by the serum concentration of apolipoprotein B (apo B) or indirectly by nuclear magnetic resonance (NMR) spectroscopy of serum to obtain NMR-derived LDL particle number (LDL-P).CONTENT: To assess the comparability of apo B and LDL-P, we reviewed 25 clinical studies containing 85 outcomes for which both biomarkers were determined. In 21 of 25 (84.0%) studies, both apo B and LDL-P were significant for at least 1 outcome. Neither was significant for any outcome in only 1 study (4.0%). In 50 of 85 comparisons (58.8%), both apo B and LDL-P had statistically significant associations with the clinical outcome, whereas in 17 comparisons (20.0%) neither was significantly associated with the outcome. In 18 comparisons (21.1%) there was discordance between apo B and LDL-P.

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Section: Comparison Of Apo B Ita/ina and Ldl-p Methodsmentioning

confidence: 99%

Association of Apolipoprotein B and Nuclear Magnetic Resonance Spectroscopy–Derived LDL Particle Number with Outcomes in 25 Clinical Studies: Assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices

Cole¹,

Contois²,

Csákó

et al. 2013

Clinical Chemistry

115

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“…Figure 5 shows the relationship between Apo B levels and CHD event rates in primary and secondary prevention studies of lipid-altering drug therapies. 160 Although subject selection was not based on Apo B for the majority of these studies, none of the trials showed a significant imbalance between groups for baseline Apo B concentration. Also, these studies varied with regard to the therapeutic regimen tested, clinical population, and Apo B assay used.…”

Section: Should Apo B Be a Target Of Therapy? If Not How Should Apo mentioning

confidence: 99%

Clinical utility of inflammatory markers and advanced lipoprotein testing: Advice from an expert panel of lipid specialists

Davidson

Ballantyne

Jacobson

et al. 2011

Journal of Clinical Lipidology

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250

178

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“…High ApoB levels could potentially be of importance for contributing to an unfavourable cardiovascular profile in AN patients, although the prognostic role of lipid metabolism markers for the incidence of and mortality due to cardiovascular disease in AN is not yet clear because of a lack of longitudinal data (Jacobson, 2011). Therefore, further research on the beneficial role of weight gain in reducing ApoB levels and its relationship to the onset of cardiovascular events is needed in AN patients.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Antioxidant Levels in Patients with Anorexia Nervosa after Oral Re‐alimentation: A Systematic Review and Exploratory Meta‐analysis

Solmi

Veronese

Luchini

et al. 2015

Euro Eating Disorders Rev

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Oxidative stress markers seem to be higher in patients with anorexia nervosa (AN) than healthy controls, but the potentially beneficial effects of weight gain is not known. We calculated random effects standardised mean differences (SMDs) as effect size measures of oxidative stress marker changes after re-alimentation reported in two or more studies, summarising others descriptively. Seven longitudinal studies (n = 104) were included. After a median follow-up period of 8 weeks, AN patients significantly increased their body mass index (15.1 ± 2.1 to 17.1 ± 2.2, p < 0.0001). This weight gain was followed by a significant increase in serum levels of the antioxidant albumin (studies = 6, SMD = 0.50, 95%CI = 0.18; 0.82, p = 0.002; I(2) = 16%) and a significant decrease in the oxidative stress marker Apolipoprotein B (studies = 2, n = 19, SMD = -0.85, 95%CI = -1.53; -0.17, p = 0.01; I(2) = 0). In one study, catalase and total antioxidant capacity increased, whilst superoxide dismutase significantly decreased. In conclusion, oral re-alimentation, even without full-weight normalisation, seems to improve oxidative stress in people with AN.

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Opening a New Lipid “Apo-thecary”: Incorporating Apolipoproteins as Potential Risk Factors and Treatment Targets to Reduce Cardiovascular Risk

Cited by 33 publications

References 127 publications

Association of Apolipoprotein B and Nuclear Magnetic Resonance Spectroscopy–Derived LDL Particle Number with Outcomes in 25 Clinical Studies: Assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices

Association of Apolipoprotein B and Nuclear Magnetic Resonance Spectroscopy–Derived LDL Particle Number with Outcomes in 25 Clinical Studies: Assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices

Clinical utility of inflammatory markers and advanced lipoprotein testing: Advice from an expert panel of lipid specialists

Oxidative Stress and Antioxidant Levels in Patients with Anorexia Nervosa after Oral Re‐alimentation: A Systematic Review and Exploratory Meta‐analysis

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