2013
DOI: 10.1098/rsfs.2013.0014
|View full text |Cite
|
Sign up to set email alerts
|

Opening windows on new biology and disease mechanisms: development of real-time in vivo sensors

Abstract: One contribution of 10 to a Theme Issue 'Molecular-, nano-and micro-devices for real-time in vivo sensing'.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2015
2015
2024
2024

Publication Types

Select...
3
2
1

Relationship

0
6

Authors

Journals

citations
Cited by 8 publications
(2 citation statements)
references
References 43 publications
0
2
0
Order By: Relevance
“…First, nucleic acids are susceptible to in vivo environments, e.g., degradation by ubiquitous nucleases and aggregation with plasma proteins; this can be a critical impediment to applications in in vivo imaging and sensing. 165 Second, the small size of aptamers sometimes can be disadvantageous; renal filtration and rapid clearance from the bloodstream can also impede their use in vivo. 166 Third, the aptamer generation is not easy; current SELEX technologies that are usually time-consuming and labor-intensive have an unsatisfactory success rate in discovery.…”
Section: Discussionmentioning
confidence: 99%
“…First, nucleic acids are susceptible to in vivo environments, e.g., degradation by ubiquitous nucleases and aggregation with plasma proteins; this can be a critical impediment to applications in in vivo imaging and sensing. 165 Second, the small size of aptamers sometimes can be disadvantageous; renal filtration and rapid clearance from the bloodstream can also impede their use in vivo. 166 Third, the aptamer generation is not easy; current SELEX technologies that are usually time-consuming and labor-intensive have an unsatisfactory success rate in discovery.…”
Section: Discussionmentioning
confidence: 99%
“…In vivo nanosensing systems [43], which can operate inside the human body in real time, have been recently proposed as a way to provide faster and more accurate disease diagnosis and treatment than traditional technologies based on in vitro medical devices. However, the sensing range of each nanosensor is limited to its close nano-environment; thus, many nanosensors are needed to cover significant regions or volumes.…”
Section: In Vivo Nano-communicationmentioning
confidence: 99%