Operant Reward Learning in
            <i>Aplysia</i>
            : Neuronal Correlates and Mechanisms

Brembs, Björn; Lorenzetti, Fred D.; Reyes, Fredy D.; Baxter, Douglas A.; Byrne, John H.

doi:10.1126/science.1069434

Cited by 306 publications

(296 citation statements)

References 31 publications

Supporting

Mentioning

275

Contrasting

Unclassified

Order By: Relevance

“…[12,33,40,45]) and, furthermore, supported the hypothesis that such studies may tap into fundamental neurobiological alterations that underlie drug addictions [7,33,58,65]. It demonstrated that a psychostimulant drug of abuse could be rewarding to an animal that, unlike mammalian species, exhibits a relatively simple neuronal organization.…”

Section: Discussionmentioning

confidence: 59%

“…Electrical stimulation [5], biogenic amines [40] or food items [45] have served as rewards in past studies of invertebrates and in some cases there has since been considerable advance into understanding the underlying proximate mechanisms of such processes (e.g., ref. [12]). A recent study, where planarians were conditioned to prefer environments associated with methamphetamine treatments, was a notable exception to the general lack of explicit studies of drug reward in invertebrate taxa [33].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ethological analyses of crayfish behavior: a new invertebrate system for measuring the rewarding properties of psychostimulants

Panksepp

Huber

2004

Behavioural Brain Research

View full text Add to dashboard Cite

Recent investigations in invertebrate neurobiology have opened up a new line of research into the basic behavioral, neurochemical and genomic alterations that accompany psychostimulant drug exposure. However, the extent to which such findings relate to changes in motivational and learning processes, such as those that typify drug addictions, remains unclear. The present study addressed this issue in the crayfish, Orconectes rusticus. The first set of experiments demonstrated that intramuscular injections of cocaine and amphetamine have robust and distinguishable effects on crayfish behavior. In the second part of the study, the reinforcing properties of psychostimulants were tested in a series of conditioned place preference experiments. Amphetamine and, to a lesser extent, cocaine were both found to serve as rewards when their intra-circulatory infusion was coupled to a distinct visual environment. The monoaminergic regulation of behavior has been extensively studied in decapod crustaceans and the present experiments demonstrated that (mammalian) drugs of abuse, capable of interfering with monoamine chemistry, are similarly rewarding to crayfish. Behavioral studies in crayfish can provide a complementary approach to using other invertebrate species in addiction research.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Ethological analyses of crayfish behavior: a new invertebrate system for measuring the rewarding properties of psychostimulants

Panksepp

Huber

2004

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…The impairment produced by PCP, a glutamatergic antagonist, correlates significantly with a decrease in DA levels only in the DLPC and in the prelimbic cortex, and is reversed by clozapine. Brembs et al, (2002) have demonstrated in Aplysia a cellular model of DA enhanced instrumental conditioning.…”

Section: Da Dysfunction and Impulsive Behaviors In Animalsmentioning

confidence: 99%

“…Recent studies suggest the involvement of DA activity in some of the circuits that are associated with the behavioral dimensions of BPD. For example, it has been suggested that the Aplysia cellular model of DA-enhanced instrumental conditioning recently demonstrated by Brembs et al (2002) may be conserved in higher animal forms, and may provide the basis for the learning of reward-seeking behaviors mediated by DA in the NAC (Rankin, 2002).…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Dopamine Dysfunction in Borderline Personality Disorder: A Hypothesis

Friedel

2004

Neuropsychopharmacol

123

View full text Add to dashboard Cite

Research on the biological basis of borderline personality disorder (BPD) has focused primarily on the serotonin model of impulsive aggression. However, there is evidence that dopamine (DA) dysfunction may also be associated with BPD. Pertinent research and review articles, identified by Medline searches of relevant topics, books, references from bibliographies, and conference proceedings from 1975 to 2003, were reviewed. Evidence of DA dysfunction in BPD derives from the efficacy of traditional and atypical antipsychotic agents in BPD, and from provocative challenges with amphetamine and methylphenidate of subjects with the disorder. In addition, human and animal studies indicate that DA activity plays an important role in emotion information processing, impulse control, and cognition. The results of this review suggest that DA dysfunction is associated with three dimensions of BPD, that is, emotional dysregulation, impulsivity, and cognitive-perceptual impairment. The main limitation of this hypothesis is that the evidence reviewed is circumstantial. There is no study that directly demonstrates DA dysfunction in BPD. In addition, the therapeutic effects of antipsychotic agents observed in BPD may be mediated by non-DA mechanisms of action. If the stated hypothesis is correct, DA dysfunction in BPD may result from genetic, developmental, or environmental factors directly affecting specific DA pathways. Alternatively, DA dysfunction in BPD may be a compensatory response to alterations in the primary neural systems that control emotion, impulse control, and cognition, and that are mediated by the brain's main neurotransmitters, glutamate, and GABA, or in one or more other neuromodulatory pathways such as serotonin, acetylcholine, and norepinephrine.

show abstract

“…Recording extracellularly from the esophageal nerve in the intact animal during a biting movement that fails to grasp food reveals little activity. However, when the animal grasps and swallows seaweed, there are bursts of activity in the esophageal nerve during and outlasting the swallowing movements [30 ]. Presumably, the esophageal nerve transmits information about the presence of food to the buccal ganglia.…”

Section: Operant Reward-learning Of Feeding Behavior In Aplysiamentioning

confidence: 99%

Operant conditioning in invertebrates

Brembs

2003

Current Opinion in Neurobiology

View full text Add to dashboard Cite

Bjö rn BrembsLearning to anticipate future events on the basis of past experience with the consequences of one's own behavior (operant conditioning) is a simple form of learning that humans share with most other animals, including invertebrates. Three model organisms have recently made significant contributions towards a mechanistic model of operant conditioning, because of their special technical advantages. Research using the fruit fly Drosophila melanogaster implicated the ignorant gene in operant conditioning in the heat-box, research on the sea slug Aplysia californica contributed a cellular mechanism of behavior selection at a convergence point of operant behavior and reward, and research on the pond snail Lymnaea stagnalis elucidated the role of a behavior-initiating neuron in operant conditioning. These insights demonstrate the usefulness of a variety of invertebrate model systems to complement and stimulate research in vertebrates.

show abstract

Operant Reward Learning in Aplysia : Neuronal Correlates and Mechanisms

Cited by 306 publications

References 31 publications

Ethological analyses of crayfish behavior: a new invertebrate system for measuring the rewarding properties of psychostimulants

Ethological analyses of crayfish behavior: a new invertebrate system for measuring the rewarding properties of psychostimulants

Dopamine Dysfunction in Borderline Personality Disorder: A Hypothesis

Operant conditioning in invertebrates

Contact Info

Product

Resources

About