This study examined the optimum coagulation conditions for reducing irreversible fouling during the in-line coagulation/ultrafiltration (UF) membrane process and assessed the decrease in operating cost. The coagulation conditions that generated charge-neutralization, sweep-flocculation, and under-dosing mechanisms were obtained by a jar-test, and a pilot-scale in-line coagulation/UF membrane process was operated under the coagulation conditions. Charge-neutralization and sweep-flocculation mechanisms reduced irreversible fouling effectively, and the under-dosing mechanism was able to reduce irreversible fouling only when flocs of a certain size or larger were formed. This revealed that floc size was a more important factor in reducing irreversible fouling than floc structure, and once initial cake layers were created by flocs of a fixed size, the structure of formed cake layers had only a minor effect on irreversible fouling. Regarding reduction in operating cost, 0.5 mg/L and 3 h, which were necessary to produce an under-dosing mechanism, were deemed the optimum coagulant dosage and coagulant injection time, respectively, to reduce irreversible fouling. In order to analyze the operating cost reduction effect, a pilot plant was operated under optimum operating conditions, and the total operating cost was approximately 11.2% lower than without in-line coagulation.The main coagulation mechanisms of a conventional treatment system are charge-neutralization and sweep-flocculation [11,12]. Charge-neutralization is the cause of unstable conditions by instilling coagulants with a positive charge into the contaminants that possess a negative charge in order to alter the zeta potential of the contaminants in question to as close to zero as possible [13]. Sweep-flocculation means that metal salt is added to water at a concentration high enough to cause precipitation of metal hydroxide. Colloidal particles can be enmeshed in these precipitates [14]. The coagulation-membrane filtration hybrid process, which consists of coagulation-flocculation-sedimentation-filtration, is a process that improves water quality and reduces membrane fouling by removing foulants through flocculation and sedimentation before membrane filtration occurs. In this process, the high removal rate of contaminants leads to improvement in the performance of the membrane filtration process. Therefore, the coagulation conditions (coagulant type, amount of feed, pH) that cause charge-neutralization and sweep-flocculation mechanisms, which were proposed as a conventional treatment process, were the optimal coagulation conditions for reducing membrane fouling [15,16].The in-line coagulation process, which can reduce the footprint of treatment, has been widely applied in membrane filtration methods as a pretreatment process to coagulation [3,16]. In this system, the coagulants may be injected "in-line" but in the absence of flocculation/sedimentation, the coagulated water will be filtered by the membrane directly. Not only destabilized contaminants or their agg...