Operating time and survival of primary total hip replacementsAn analysis of 31 745 primary cemented and uncemented total hip replacements from local hospitals reported to the Norwegian Arthroplasty Register 1987–2001

Does cement increase the risk of infection in primary total hip arthroplasty? Revision rates in 56,275 cemented and uncemented primary THAs followed for 0–16 years in the Norwegian Arthroplasty Register

“…This seems plausible, since increased contamination might be expected from longer duration of the surgery. Similar results have been reported previously from the Norwegian Arthroplasty Register (Småbrekke et al 2004). In the present and previous studies, we have demonstrated reduced revision due to aseptic loosening with antibiotic in the cement (Espehaug et al 1997, Engesaeter et al 2003.…”

Prosthetic Joint Infection Risk after TKA in the Medicare Population

“…Previous studies of infection risk have been singleinstitution reviews of retrospective clinical data starting as early as the 1970s [2, 16-19, 22, 23] or registry studies from Scandinavia [6,7,21] and thus may not be generalizable to the modern national population of joint arthroplasty recipients in the United States. A recent study related to antibiotic-related bone cement, drawn in part from the European registry experience, noted a lack of controlled clinical trials related to the treatment of infection [14].…”

“…A recent study related to antibiotic-related bone cement, drawn in part from the European registry experience, noted a lack of controlled clinical trials related to the treatment of infection [14]. Despite these limitations, observational studies conducted over the past three decades suggest multiple factors may be implicated in the infection risk for patients undergoing arthroplasty, including increased operative time, longer hospital stay, obesity, simultaneous bilateral joint arthroplasty, and diagnoses of rheumatoid arthritis, myocardial infarction, and atrial fibrillation, and the lack of use of certain infection countermeasures such as antibiotic bone cement [6,14,17,18,21,23]. Thus, the current relative risk of infection in contemporary TKA as well as the relative importance of various risk factors remains under debate attributable both to the rarity of the complication, changes in the treatment and prevention of infection over time as well as the practical difficulties associated with conducting well-controlled clinical studies on this topic with long-term followup.…”

Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-α gene promoter, and transforming growth factor-β1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study

“…Aseptic loosening is more likely to occur earlier after arthroplasty with certain types of prosthetic devices/materials, for example with Endler polyethylene cups or cemented and smooththreaded uncemented cups as opposed to coated uncemented cups, and with cemented or uncoated uncemented femoral stems as opposed to coated uncemented stems [1][2][3][4] . Also, aseptic loosening is likely to occur earlier with less experienced surgeons 5,6 . Patients requiring hip arthroplasty due to developmental hip dysplasia (DDH) or complications of the femoral neck fracture are likely to develop aseptic loosening earlier than the patients with primary osteoarthritis 7 .…”