This paper proposes a highly efficient single-phase three-level neutral point clamped (NPC) converter operated by a model predictive control (MPC) method with reduced commutations of switches. The proposed method only allows switching states with none or a single commutation at the next step as candidates for future switching states for the MPC method. Because the proposed method preselects switching states with reduced commutations when selecting an optimal state at a future step, the proposed method can reduce the number of switchings and the corresponding switching losses. Although the proposed method slightly increases the peak-to-peak variations of the two dc capacitor voltages, the developed method does not deteriorate the input current quality and input power factor despite the reduced number of switching numbers and losses. Thus, the proposed method can reduce the number of switching losses and lead to high efficiency, in comparison with the conventional MPC method.