Operation for lung cancer in patients with idiopathic pulmonary fibrosis: surgical contraindication?

Clinical Impact of Interstitial Pneumonia Following Surgery for Lung Cancer

“…In 3 patients, AIP developed unpredictably without underlying interstitial lesions. Case #9, without IP preoperatively, showed a typical fulminant course that was very similar to previous reports [3,12]. Original Thoracic…”

Surgical Outcomes of Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema and Those with Idiopathic Pulmonary Fibrosis without Emphysema

“…Previous studies [20][21][22][23][24][25] reported that postoperative respiratory complications were found in 26%-54.0% of patients with IPF, moderately higher than in the present study, in which the CPFE group had a significantly higher rate of cardiopulmonary morbidity than the IPF alone group; this was assumed to be due to the fact that postoperative PFT decreased unexpectedly in CPFE, involving both %VC and FEV1%, because the CPFE patients experienced AE at almost the same rate as IPF patients without emphysema and required more HOT than IPF patients without emphysema. Moreover, previous studies 7,9,10,14) noted that CPFE was highly associated with pulmonary hypertension, which might be regarded as a cause of more 19) reported that postoperative pulmonary complications occurred in 20% of CPFE patients.…”

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

“…In patients who received surgical treatment for lung cancer, post-operative mortality (e.g. 30-day, 90-day, in-hospital) tended to be low (0 deaths [95,96], 4% [96,97], 5% [98], 7% [97], 8% [98,99], 12% [93,98]), although a small database review from China reported a post-operative mortality rate of 33.3% (two of six patients) [84]. Median survival from IPF diagnosis was between 7 (95% CI 2.51-11.49) and 26.9 months (95% CI 14.67-39.05) [84,89].…”