Operation for lung cancer in the elderly: What about octogenarians?

Riquet, Marc; Manac'h, D; Pimpec‐Barthes, Françoise Le; Debrosse, Denis; Dujon, Antoine; Saab, M; Debesse, B

doi:10.1016/0003-4975(94)90803-6

Cited by 15 publications

(4 citation statements)

References 2 publications

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“…Long-term survival in cancer patients with nodal (N2) or T3N0 disease showed disappointing results. Similarly, Riquet et al reported a median survival of only 11 months in N2 patients over 75 years of age, in contrast to 20% 5-year and 18-month median survivals in those younger than 75 [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Are Extensive Open Lung Resections for Elderly Patients with Lung Cancer Justified?

et al. 2023

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Background: Older patients with malignancies are more comorbid than younger ones and are usually undertreated only because of their age. The aim of this study is to investigate the safety of open anatomical lung resections for lung cancer in elderly patients. Methods: We retrospectively analyzed all patients who underwent lung resection for lung cancer in our institution and categorized them into two groups: the elderly group (≥70 years old) and the control (<70). Results: In total, 135 patients were included in the elderly group and 375 in the control. Elderly patients were more frequently diagnosed with squamous cell carcinoma (59.3% vs. 51.5%, p = 0.037), higher differentiated tumors (12.6% vs. 6.4%, p = 0.014), and at an earlier stage (stage I: 55.6% for elderly vs. 36.6%, p = 0.002). Elderly patients were more vulnerable to postoperative pneumonia (3.7% vs. 0.8%, p = 0.034), lung atelectasis (7.4% vs. 2.9%, p = 0.040), and pleural empyema (3.2% vs. 0%, p = 0.042), however, with no increased 30-day-mortality (5.2% for elderly vs. 2.7%, p = 0.168). Survival was comparable in both groups (43.4 vs. 45.3 months, p = 0.579). Conclusions: Elderly patients should not be excluded from open major lung resections as the survival benefit is not reduced in selected patients.

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Section: Discussionmentioning

confidence: 99%

Are Extensive Open Lung Resections for Elderly Patients with Lung Cancer Justified?

et al. 2023

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“…7 There have been many reports detailing the outcomes of lung resection in the elderly. [24][25][26][27][28][29][30][31][32][33][34][35] It is difficult to compare these reports because they have occurred over a long period of time with different populations of patients. They have reported different outcomes over different follow-up periods.…”

Section: Agementioning

confidence: 99%

Lung Cancer: Preoperative Pulmonary Evaluation of the Lung Resection Candidate

Poonyagariyagorn¹,

Mazzone²

2008

Semin Respir Crit Care Med

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Lung resection provides the best chance of cure for individuals with early-stage non-small-cell lung cancer. Lung resection will lead to a decrease in lung function. The population that develops lung cancer often has concomitant lung disease and a reduced ability to tolerate further losses in lung function. The goal of the preoperative pulmonary assessment of individuals with resectable lung cancer is to identify those individuals whose short- and long-term morbidity and mortality would be unacceptably high if surgical resection were to occur. Pulmonary function measures such as the forced expiratory volume in 1 second (FEV1) and the diffusing capacity for carbon monoxide (DLCO) are useful predictors of postoperative outcome. When lung function in not normal, the prediction of postoperative lung function from preoperative results, and the assessment of exercise capacity, can help to clarify the risks. Testing algorithms and published guidelines help to direct the order of testing. Interventions that allow us to consider resection outside of the guidelines, or to maximize the potential to tolerate lung resection, help us to offer potentially curative treatment to as many as possible. Knowledge of alternative treatment options will help to guide those deemed unfit for resection.

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“…Ceux atteints de cancer du poumon sont devenus une préoccupation au quotidien, avec des âges de plus en plus avancés. La littérature commence progressivement à s'étoffer [1][2][3][4] et une revue générale [5] suivie d'une étude rétrospective multicentrique [6] ont récemment fait un point sur le sujet. La très grande variabilité des situations observées dans la population des personnes âgées rend difficile la standardisation des propositions thérapeutiques.…”

Section: Introductionunclassified