This paper proposes a Symmetric High Voltage-Gain (SHVG) boost converter control for photovoltaic system applications. The concept is based on a multilevel boost converter configuration, which presents an advantage compared to a classic boost converter such as the ability to transfer a high amount of power with less stress on the power electronics components in the high voltage-gain conditions. This advantage allows the power losses in the converter to be reduced. A mathematical-based voltage model of the PV system using variable series resistance depending on solar irradiance and the temperature is proposed. This model is connected to an SHVG boost converter to supply the load’s power. A control strategy of the DC-bus voltage with maximum power point tracking (MPPT) from the PV system using PI controllers is developed. The contributions of the paper are focused on the SHVG operating analysis with the passive components’ sizing, and the DC-bus voltage control with maximum power point tracking of the PV systems in dynamic operating conditions. The performances of the proposed control are evaluated through simulations, where the results are interesting for high-power photovoltaic applications.