Operation of chemically sensitive field-effect sensors as a function of the insulator-electrolyte interface

Bousse, Luc; Rooij, N. F. de; Bergveld, Piet

doi:10.1109/t-ed.1983.21284

Cited by 548 publications

(380 citation statements)

References 40 publications

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“…The surface potential change Δφ0 with respect to a pH value change� 0 � has been derived from the site-binding (SB) and Gouy-Chapman-Stern (GCS) model [9][10][11][12][13], Eq. 5:…”

Section: Principle Of Operationmentioning

confidence: 99%

“…The second structure has a density of 8 SiNW/µm in the vertical direction and 2.4 SiNW/µm in the horizontal direction. Devices with varying number of SiNWs in the horizontal direction (10,15 and 20 NWs) and source to drain lengths (2, 3, 4 μm) were fabricated. The fabrication process has been presented in detail in an earlier publication [19].…”

Section: Sensitivitymentioning

confidence: 99%

See 1 more Smart Citation

Electrical characterization of high performance, liquid gated vertically stacked SiNW-based 3D FET biosensors

Buitrago

Badia

Georgiev

et al. 2014

Sensors and Actuators B: Chemical

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“…The surface potential change Δφ0 with respect to a pH value change� 0 � has been derived from the site-binding (SB) and Gouy-Chapman-Stern (GCS) model [9][10][11][12][13], Eq. 5:…”

Section: Principle Of Operationmentioning

confidence: 99%

Section: Sensitivitymentioning

confidence: 99%

Electrical characterization of high performance, liquid gated vertically stacked SiNW-based 3D FET biosensors

Buitrago

Badia

Georgiev

et al. 2014

Sensors and Actuators B: Chemical

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“…Since then, the research efforts have concentrated in the first place on clarifying the operational mechanism of devices of this type having inorganic gate materials . It appeared that the operation could be described by applying the site-dissociation model to the electrolyte/gate interface, resulting in the definition of a specific sensitivity parameter, characteristic for each type of inorganic gate material [18] .…”

Section: Fet-based Sensorsmentioning

confidence: 99%

Sensors and actuators, Twente

Bergveld

1989

Sensors and Actuators

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This paper describes the organization and the research programme of the Sensor and Actuator (S&A) Research Unit of the University of Twente, Enschede, the Netherlands . It includes short descriptions of all present projects concerning : micromachined mechanical sensors and actuators, optical sensors, recording media and sensors based on magnetic materials, FET-based sensors and systems and the integration of electronic functions and systems in sensor chips .

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“…The so-called threshold voltage of the transistor is, however, a function of the pH of the analyte which contains a reference electrode contacted to the common of the specially developed ISFET amplifier (Bergveld, 1981). The operational mechanism of the ISFET originates from the pH sensitivity of the inorganic gate oxide, such as SiOZ, A1203, Si3N4 or Ta,O+ This mechanism is purely a surface phenomenon which can be explained by the site dissociation model (Bousse et al, 1983). Surface hydroxyl groups react with the analyte in an acidic or a basic manner, resulting in a corresponding surface charge and potential.…”

Section: The Isfetmentioning

confidence: 99%

ISFET based enzyme sensors

1987

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This paper reviews the results that have been reported on ISFET based enzyme sensors. The most important improvement that results from the application of ISFETs instead of glass membrane electrodes is in the method of fabrication. Problems with regard to the pH dependence of the response and the dynamic range as well as the influence of the sample buffer capacity have not been solved. As a possible solution we introduce a coulometric system that compensates for the analyte buffer capacity. tf the pH in the immobilized enzyme layer is thus controlled, the resulting pH-static enzyme sensor has an output that is independent of the sample pH and buffer capacity and has an expanded linear range.Key words: ISFET, enzyme, urea, K-technology, buffer dependence, coulometry, pH-static enzyme sensor. INlXODUCTIONPotentiometrically operating enzyme sensors suffer from a number of problems, partly due to the properties of immobilized enzymes and partly resulting from the use of the particular ion sensitive electrode. Focussing on enzyme electrodes in which the conversion of a substrate causes a change in the local pH, these problems are: pH-dependence of response, detection limit and dynamic range; response dependency on the analyte buffer capacity; dependence on immobilization technology; and individual membrane casting and control of membrane thickness. 161Biosensors 0265-928X/88/$03-50

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Operation of chemically sensitive field-effect sensors as a function of the insulator-electrolyte interface

Cited by 548 publications

References 40 publications

Electrical characterization of high performance, liquid gated vertically stacked SiNW-based 3D FET biosensors

Electrical characterization of high performance, liquid gated vertically stacked SiNW-based 3D FET biosensors

Sensors and actuators, Twente

ISFET based enzyme sensors

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