In the present study, develop the multi zone thermodynamic model for the simulation of a small diesel engine operating on the mixture of diesel and ethanol and comparing results with an experiment. This paper discussed analytically and provides data of nitrogen oxide and performance parameters such as power, speci-20 Paramust Juntarakod and Thanakom Soontornchainacksaeng fic fuel consumption and thermal efficiency, indicated mean effective pressure. For this purpose, quasi-dimensional phenomenological three zone combustion process (unburned, adiabatic core region and boundary layer gas) has been modeled based on equilibrium constants method with MATLAB program to calculate the mole fractions of 11 combustion products when the new equilibrium constants function developed by Gill which are lowly-highly temperature dependent. To compute diesel engine cycles, zero-dimensional compression and expansion model have given by Ferguson and developed with new assumptions. These results involve various combination sequence effects of compression ratio (23-25), equivalence ratio (0.8-0.9), burn duration angle (60-70 CA) and engine speed (1000-1500 rpm) which volume fraction of fuel compositions (10-30% ethanol) (Diesel-Ethanol blend). The results of the study as the power was calculated by this method are the error range within around 5% or 0.5 kW from the maximum experiment results. The specific fuel consumption was less than 5% or 15-20 g (Fuel)/kW-hr from experiment results. The resulted show that nitrogen oxide has changed very little, corresponding results of various sequence effects. The performance parameters were changed with varying engine computing conditions. Maximum performance parameters be raised by increases the engine speed and equivalence ratio, its can increase the thermal efficiency are approximately value 15-20%.