Background: As a result of the effort to satisfy unique customer needs, the complexity of production and service processes is constantly increasing. In this context, the requirements for packaging systems, essential for carrying out logistic tasks, are also diversifying, and various quality defects and problems are appearing more and more frequently. Methods: The research used an inductive method. While practical problems were being solved, the need for developing the concept of a packaging inspection framework arose, the lack of which was also supported by a systematic literature review. Results: During the concept’s development, packaging errors found in the literature were identified and methods for detection and solution were systematized. A general framework was developed to identify and eliminate these errors. The applicability of the developed method was demonstrated through a complex case study, and its accuracy was verified. Conclusions: This research is important because, instead of using “island” solutions, in the future, companies will have a general framework available to them for handling all packaging-related errors according to a predefined methodology. This can reduce the time required for problem-solving and increase efficiency, which is a significant competitive factor.