Operational strategies in US cancer centers of excellence that support the successful accrual of racial and ethnic minorities in clinical trials

Regnante, Jeanne M.; Richie, Nicole; Fashoyin-Aje, Lola A.; Hall, Laura Lee; Highsmith, Quita; Louis, J'Aimee A.; Turner, K. C.; Hoover, Spencer C.; Lee, Simon J. Craddock; González, Evelyn; Williams, E. L.; Adams, Homer; Obasaju, Coleman K.; Sargeant, Ify; Spinner, Jovonni; Reddick, Christopher G.; Gandee, Marianne; Geday, Madeline; Dang, Julie; Watson, Rayneisha; Chen, Moon S.

doi:10.1016/j.conctc.2020.100532

Cited by 27 publications

(45 citation statements)

References 16 publications

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“…Better management and assignment of catchment areas for designated cancer centers could help tailor such outreach activities 26 . Operational frameworks and allocated resources have already been set in place at many cancer centers of excellence in the United States who report racial/ethnic minority research inclusion rates of up to 50%, and these serve as a great example for the right path forward 27,28 …”

Section: What Can We Do About It?mentioning

confidence: 99%

“…26 Operational frameworks and allocated resources have already been set in place at many cancer centers of excellence in the United States who report racial/ethnic minority research inclusion rates of up to 50%, and these serve as a great example for the right path forward. 27,28 Coordination with primary care physicians and community health centers is crucial, however, one should acknowledge that these physicians and centers are often stretched to capacity. 29 In fact, qualitative studies indicate that although community care providers may be interested in having clinical trial options available for their patients, they often do not have time to search for and inform patients about available trials.…”

Section: Optimizing Patients' Access To Clinical Trials In the Communitymentioning

confidence: 99%

“…Study populations in clinical research must reflect changing demographics in the United States and globally, especially in the era of precision medicine. 27 Participation in clinical trials itself may ameliorate observed disparities in cancer outcomes, because clinical trials can provide access to evidence-based medicines. 58,59 Achieving cancer health equity through optimizing diversity in clinical trials is a national and global imperative, and everyone has a role to play.…”

Section: Uniform Reporting Of Study Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Addressing racial/ethnic disparities in cancer clinical trials: Everyone has a role to play

Habr

Ferdinand

2021

Cancer

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Section: What Can We Do About It?mentioning

confidence: 99%

Section: Optimizing Patients' Access To Clinical Trials In the Communitymentioning

confidence: 99%

Section: Uniform Reporting Of Study Outcomesmentioning

confidence: 99%

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Addressing racial/ethnic disparities in cancer clinical trials: Everyone has a role to play

Habr

Ferdinand

2021

Cancer

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“…20 Some disease-focused recruitment strategies have been recommended such as for Alzheimer's disease 21 and cancer research. 22 Step…”

Section: Step 2: Specify Recruitment Processes By Stagementioning

confidence: 99%

Guidelines for Evaluating the Feasibility of Recruitment in Pilot Studies of Diverse Populations: An Overlooked but Important Component

et al. 2020

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Background: In health disparities research, studies often fall short of their recruitment goals. Conducting a pilot feasibility study of recruitment in which data are collected systematically on recruitment processes can help investigators refine methods for the larger study. However, there are few guidelines for conducting pilot feasibility studies, and recruitment methods are seldom the focus. Feasibility indicators differ from traditional reports of recruitment results by focusing on the extent to which recruitment goals are met.Methods: We present an organizing framework for assessing the feasibility of recruitment that includes eight steps, briefly: 1) specify recruitment goals; 2) specify recruitment processes; 3) establish a tracking system for each individual; 4) establish a tracking database for monitoring processes and results; 5) implement recruitment and track each individual’s progress; 6) summarize recruitment results; 7) calculate and interpret feasibility measures - were goals met; and 8) if goals were not met, utilize tracking data to modify methods for the larger study. We describe methods within each step, with added details for steps 2-5 (the specific processes). The framework draws from a small literature on recruitment feasibility with a focus on health disparities populations. The guidelines blend well-known methods of recruitment with additional information on calculating feasibility indicators.Conclusion: These guidelines provide a first step in thinking systematically about recruitment feasibility, to advance the field of measuring feasibility. Feasibility indicators also can be used to track the effectiveness of innovative recruitment strategies as part of building the science of recruitment, especially in disparities populations. Ethn Dis. 2020; 30(Suppl 2):745-754; doi:10.18865/ed.30.S2.745

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“…A coordinated multistakeholder focus on sometimes simultaneously occurring multilevel interventions that affect health-interpersonal, organizational, community, educational, occupational, environmental, and policy-is required to enable high-impact CCC practices at a local level. 38 Although our earlier work described notable practices for recruiting racial and ethnic minority groups into cancer clinical trials, 39,40 this paper explains the development of a framework for addressing cancer care disparities across the CCC, guided by the Institute of Medicine/National Academies of Sciences, Engineering, and Medicine (IOM/NAS)established CCC domains. 41 Because practices and efforts are not routinely documented or published, we selected a workshop approach bringing together experts across the CCC as an effective method for framework development.…”

Section: Introductionmentioning

confidence: 99%

Development of an Actionable Framework to Address Cancer Care Disparities in Medically Underserved Populations in the United States: Expert Roundtable Recommendations

Winkfield

Regnante

Miller‐Sonet

et al. 2021

JCO Oncology Practice

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PURPOSE: Cancer disparities persist among medically underserved populations despite widespread efforts to address them. We describe the development of a framework for addressing cancer care disparities across the cancer care continuum (CCC), guided by the CCC domains established by the Institute of Medicine/National Academies of Sciences, Engineering, and Medicine (IOM/NAS). MATERIALS AND METHODS: An environmental scan was conducted to identify strategies and associated experts who are providing or have successfully provided community- and/or patient-centric IOM/NAS-defined domain standards to our target populations. A multistakeholder expert roundtable working group was convened for framework development. A premeeting survey informed agenda development, documented expert practices for target populations, and identified priority areas for meeting focus. RESULTS: The environmental scan identified 84 unique experts across 8 stakeholder groups and 44 patient organizations; 50 were invited to the roundtable and 33 participated. They broadly represented disease sites, geography, and experience with target populations and all CCC domains. The premeeting survey (16 responses) identified coordination of care or patient navigation (66.7%), community engagement (60.0%), and healthcare system changes (53.3%) as priority focus areas. The experts identified access and treatment barriers or gaps within and between CCC domains, specified key notable practices to address these, and developed an actionable framework and recommendations for each priority focus area. CONCLUSION: The framework and recommendations are intended to guide researchers, healthcare leaders, advocates, community- and patient-focused service organizations, and policy leaders to address and promote health equity in cancer care access and treatment outcomes.

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Operational strategies in US cancer centers of excellence that support the successful accrual of racial and ethnic minorities in clinical trials

Cited by 27 publications

References 16 publications

Addressing racial/ethnic disparities in cancer clinical trials: Everyone has a role to play

Addressing racial/ethnic disparities in cancer clinical trials: Everyone has a role to play

Guidelines for Evaluating the Feasibility of Recruitment in Pilot Studies of Diverse Populations: An Overlooked but Important Component

Development of an Actionable Framework to Address Cancer Care Disparities in Medically Underserved Populations in the United States: Expert Roundtable Recommendations

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