The term "problem site" is based on a constellation of factors including the disease itself, the anatomic site, the resulting excision defect and choice of the most appropriate wound closure technique. Typical problem sites are the nose, eyelids, hands (fingers and nails) and the anogenital region, each of which is a functional-aesthetic entity. As dermatologic surgeons become even more experienced in plastic and reconstructive surgery, the term"problem sites" will be used less often.