Operative Modalities and Effects of BNCT on Liver Metastases of Colon Adenocarcinoma

Pinelli, T.; Altieri, S.; Fossati, F.; Zonta, A.; Ferrari, Cinzia; Prati, U.; Roveda, L.; Tata, S. Ngnitejeu; Barni, Sergio; Chiari, Patrizia; Nano, Rosanna; Ferguson, D. M.

doi:10.1007/978-1-4615-1285-1_216

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…It is regrettable that the technical procedures and the physical basis as well as the clinical background have not yet been published in detail. Most of the information reported in this article regarding the Pavia case has been taken from conference proceedings (4,23,34,35) and is based on oral public presentations 3,8 and personal communications. 2 Regarding the neutronics, the published work from Pavia (4,23,35) is based on a thermal column.…”

Section: Discussionmentioning

confidence: 99%

Design of a Rotating Facility for Extracorporal Treatment of an Explanted Liver with Disseminated Metastases by Boron Neutron Capture Therapy with an Epithermal Neutron Beam

et al. 2006

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In 2001, at the TRIGA reactor of the University of Pavia (Italy), a patient suffering from diffuse liver metastases from an adenocarcinoma of the sigmoid was successfully treated by boron neutron capture therapy (BNCT). The procedure involved boron infusion prior to hepatectomy, irradiation of the explanted liver at the thermal column of the reactor, and subsequent reimplantation. A complete response was observed. This encouraging outcome stimulated the Essen/Petten BNCT group to investigate whether such an extracorporal irradiation could be performed at the BNCT irradiation facility at the HFR Petten (The Netherlands), which has very different irradiation characteristics than the Pavia facility. A computational study has been carried out. A rotating PMMA container with a liver, surrounded by PMMA and graphite, is simulated using the Monte Carlo code MCNP. Due to the rotation and neutron moderation of the PMMA container, the initial epithermal neutron beam provides a nearly homogeneous thermal neutron field in the liver. The main conditions for treatment as reported from the Pavia experiment, i.e. a thermal neutron fluence of 4 x 10(12) +/- 20% cm(-2), can be closely met at the HFR in an acceptable time, which, depending on the defined conditions, is between 140 and 180 min.

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Section: Discussionmentioning

confidence: 99%

Design of a Rotating Facility for Extracorporal Treatment of an Explanted Liver with Disseminated Metastases by Boron Neutron Capture Therapy with an Epithermal Neutron Beam

et al. 2006

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“…In vivo researches were performed in rats bearing metastases obtained with the intrasplenic injection of neoplastic cells from the line mentioned above. As the carrier of B we used 10 BPA, a substance that appears to be uptaken by cancer cells with an active transport mechanism so that 10 B concentration in cells can be higher than the one in interstitial fluid and culture medium.…”

Section: The Experimental Premises and Preclinical Validationmentioning

confidence: 99%

“…Experiments for the in vitro evaluation of radiation effects were performed on cells maintained for 18 hours in 20 ppm 10 BPA enriched medium and then, after washing, exposed to neutron irradiation (7x10 12 cm -2 , 10'). Immediately at the end of treatment cells were seeded in both culture flasks, one for each observation time (1,2,5,7,9,12,15,21 days), and Petri dishes: the first seeding was intended for cell counting and DNA analysis, the second for plating efficiency test.…”

Section: The Experimental Premises and Preclinical Validationmentioning

confidence: 99%

“…In late 2001, having obtained the approval of Ethics Committee of our Hospital and of Ministry of Health, we started the program of clinical applications of BNCT on an isolated liver [10].…”

Section: The Clinical Applicationsmentioning

confidence: 99%

“…According to the concept first proposed by Pinelli et al [1,2,3], the ideal situation would be the one of an organ explanted after being loaded with a 10 B compound, dipped into an homogenous neutron field and then reconnected to the patient. This way, not only a portion but the whole volume of the diseased organ would be exposed to the neutron flux, so that the dose of the absorbed radiation could be the same in any known or unknown neoplastic nodule, depending merely on 10 B concentrations in their cells. In the case of the liver, from the surgical point of view, this project was feasible, and is named "ex situ liver autotransplantation".…”

Section: Introductionmentioning

confidence: 99%

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Clinical lessons from the first applications of BNCT on unresectable liver metastases.

Zonta

Prati

Roveda

et al. 2006

J. Phys.: Conf. Ser.

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After a long series of studies on the effects of neutron irradiation of 10 B loaded neoplastic cells both in culture and in animal experiments, we started the clinical application of BNCT on humans affected by liver metastases of a radically resected colon adenocarcinoma. The procedure we adopted includes a first surgical phase, with hepatectomy; a radiotherapeutic phase, in which the isolated liver, washed and chilled, is extracorporeally irradiated with thermal neutrons; and then a second surgical phase for the reconnection of the liver to the patient. Until now two patients have been subjected to the BNCT treatment. The first one survived 44 months with a good quality of life, and died because of diffuse recurrences of his intestinal tumour. The second patient had the same early perioperative course, but after 33 days a worsening of a dilatative cardiomyopaty, from which he was suffering, determined a cardiac failure and eventually death. This clinical experience, although limited, has shown that extracorporeal neutron irradiation of the liver is a feasible procedure, able to ensure the complete destruction of liver metastases and a possible long lasting survival. In our patients neutron irradiation caused massive cellular necrosis highly specific to tumour cells, whereas normal cells were mostly spared. Nevertheless, the impact of such a traumatic operation on the patient's organism must be taken into account. Finally, we have to be aware that the fight against tumour rarely leads to a complete victory. We now have an innovative weapon which is both powerful and partly unsettled: it must be refined and above all used.

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Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies

Schwint

Hughes

Garabalino

et al. 2018

Boron‐Based Compounds

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Operative Modalities and Effects of BNCT on Liver Metastases of Colon Adenocarcinoma

Cited by 12 publications

References 10 publications

Design of a Rotating Facility for Extracorporal Treatment of an Explanted Liver with Disseminated Metastases by Boron Neutron Capture Therapy with an Epithermal Neutron Beam

Design of a Rotating Facility for Extracorporal Treatment of an Explanted Liver with Disseminated Metastases by Boron Neutron Capture Therapy with an Epithermal Neutron Beam

Clinical lessons from the first applications of BNCT on unresectable liver metastases.

Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies

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