Background: Endotracheal intubation is a routine procedure in the ICU that may save a patient's life. The stridor probability after extubation increases with a smaller cuff-leak volume. This research aimed to estimate the efficiency of the cuff leak test vs. laryngeal U/S in identifying postextubation stridor in prone surgical patients under general anesthesia. Methods: Seventy-five adults with ASA status I or II who would be undergoing prone, general anesthetic, and elective spine surgery took part in this prospective cohort research. All patients underwent a complete medical history, physical examination, laboratory tests, and laryngeal ultrasonography. Cases were examined for post-extubation syndrome (PES) and the necessity for reintubation. Results: PES occurred only in 15 (20%) patients. Cut-off pressure, CLT for PES, and air column width before deflation were insignificantly different between the entire population and the PES group. ACWD was a significant predictor of PES incidence at a cut-off value of 0.8 mm, AUC = 0.715, and P = 0.02 with 71.43% sensitivity, 78.33% specificity, 43.5% PPV, and 92.2% NPV. CLT was an insignificant predictor of PES incidence. Conclusions: The US measurement of ACWD is a reliable method of forecasting PES.