Operative treatment of avascular necrosis of the femoral head after slipped capital femoral epiphysis

Bartoníček, Jan; Vávra, J; Bartoška, Radek

doi:10.1007/s00402-010-1161-9

Cited by 11 publications

(20 citation statements)

References 13 publications

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“…In the present study MRI scans revealed an edema and a spot-like high level signal in the right femoral head. These results are consistent with the image characteristics of ANFH (24). The histopathological methodologies used in the present study, including H&E, Sudan Ш and PATH staining revealed that the rabbit model of ANFH was successfully established.…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

“…Chemokines are small molecular weight proteins (8–13 kDa) and are categorized into four different families (CC, CXC, CX3C and C) based on the presence of NH 2 terminal cysteine motifs (24). Chemokine receptors are typical G protein-coupled transmembrane proteins (24). When the associated chemokine ligand binds with the chemokine receptor, Gα1 and Gβ-γ subunits dissociate and activate phosphatidylinositol 3-kinase and small Rho guanosine triphosphatase, which leads to cellular calcium influx (25).…”

Section: Discussionmentioning

confidence: 99%

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Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head

Zhang

et al. 2019

Exp Ther Med

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The present study aimed to explore the potential of combined treatment with mesenchymal stem cells (MSCs) and danshen for angiogenesis and bone regeneration in a rabbit model of avascular necrosis of femoral head (ANFH). A rabbit model of ANFH was established using the Shwartzman reaction with methylprednisolone and Escherichia coli endotoxin injection. Magnetic resonance imaging (MRI) and histopathological examination were used to evaluate the rabbit model of ANFH. The rabbits were randomly divided into the danshen group, the MSCs group, the danshen combined with MSCs group and the model group (treated with physiological saline). The expression level of monocyte chemoattractant protein-1 (MCP-1) and stromal cell-derived factor-1 (SDF-1) were determined by reverse transcription polymerase chain reaction (RT-PCR). The expression level of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) were detected by immunofluorescence and the mRNA expression of BMP-2 and VEGF were detected by RT-PCR. Typical osteonecrosis occurred in the rabbit model of ANFH, which indicated that the model was successfully established. MCP-1 and SDF-1 were significantly increased in the model group compared with the normal group (P<0.05). Following the administration of MSCs and Salvia miltiorrhiza (danshen), MSCs labeled with 5-bromo-2-deoxyuridine were observed to be gathered in the necrotic area. The increased migration of MSCs to the necrotic area may be due to the upregulated expression of the chemokines MCP-1 and SDF-1. ANFH treated with danshen combined with MSCs may promote revascularization by increasing the expression of VEGF and BMP-2 in the femoral head, promoting re-ossification and revascularization. Danshen combined with the transplantation of MSCs may be regarded as a novel therapy for the treatment of ANFH in a clinical setting.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head

Zhang

et al. 2019

Exp Ther Med

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“…Although promising results have been reported using proximal femoral osteotomies for the treatment of partial AVN in SCFE patients during childhood [30], the development of late degenerative changes is the more frequent scenario in these patients. Despite its limits, the good results of our study suggest that THR is a safe procedure in patients who suffer from SCFE.…”

Section: Discussionmentioning

confidence: 98%

Outcomes of total hip replacement in patients with slipped capital femoral epiphysis

Traina

Fine

Abati

et al. 2012

Arch Orthop Trauma Surg

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“…The most worrisome complication of treatment is AVN of the femoral head, which is strongly associated with SCFE instability [50,65,66,84]. AVN is recognized as a risk factor for early development of severe osteoarthritis of the hip [6,37,39]. In the past, two classic studies defined the role of in situ fixation in the treatment of SCFE as a safe and reliable method [10,11].…”

Section: Search Strategies and Criteriamentioning

confidence: 99%

Slipped Capital Femoral Epiphysis: Prevalence, Pathogenesis, and Natural History

Novais

Millis

2012

Clinical Orthopaedics &Amp; Related Research

135

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Background Obesity is a risk factor for developing slipped capital femoral epiphysis (SCFE). The long-term outcome after SCFE treatment depends on the severity of residual hip deformity and the occurrence of complications, mainly avascular necrosis (AVN). Femoroacetabular impingement (FAI) is associated with SCFE-related deformity and dysfunction in both short and long term. Questions/Purposes We examined obesity prevention, early diagnosis, reducing AVN and hip deformity as strategies to reduce SCFE prevalence, and the long-term outcomes after treatment. Methods A search of the literature using the PubMed database for the key concepts SCFE and treatment, natural history, obesity, and prevalence identified 218, 15, 26, and 49 abstracts, respectively. Where Are We Now? A correlation between rising childhood obesity and increasing incidence of SCFE has been recently reported. Residual abnormal morphology of the proximal femur is currently believed to be the mechanical cause of FAI and early articular cartilage damage in SCFE. Where Do We Need to Go? Reducing the increasing prevalence rate of SCFE is important. Treatment of SCFE should aim to reduce AVN rates and residual deformities that lead to FAI to improve the long-term functional and clinical outcomes. How Do We Get There? Implementing public health policies to reduce childhood obesity should allow for SCFE prevalence to drop. Clinical trials will evaluate whether restoring the femoral head-neck offset to avoid FAI along with SCFE fixation allows for cartilage damage prevention and lower rates of osteoarthritis. The recently described surgical hip dislocation approach is a promising technique that allows anatomic reduction with potential lower AVN rates in the treatment of SCFE.

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Operative treatment of avascular necrosis of the femoral head after slipped capital femoral epiphysis

Abstract: VFITO provides a good outcome at medium-term follow-up in adolescent patients with partial ANFH after SCFE.

Cited by 11 publications

References 13 publications

Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head

Angiogenesis and bone regeneration by mesenchymal stem cell transplantation with danshen in a rabbit model of avascular necrotic femoral head

Outcomes of total hip replacement in patients with slipped capital femoral epiphysis

Slipped Capital Femoral Epiphysis: Prevalence, Pathogenesis, and Natural History

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