OPG/RANK/RANKL signaling system and its significance in nephrology.

Klejna, Katarzyna; Naumnik, Beata; Gasowska, Katarzyna; Myśliwiec, M

doi:10.2478/v10042-009-0035-x

Cited by 32 publications

(24 citation statements)

References 56 publications

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“…Several studies have indicated that bone metabolism-related hormones can stimulate bone tissue cells to produce IGF-1, TGF-β, IL-1 and IL-6 (McGee, Bamberg, Vitkus, & McGhee, 1995;Rubin et al, 2002;Zhang, Ahmad, & Gronowicz, 2003). These serum cytokines regulate bone resorption by osteoclasts by changing the ratio of RANKL/OPG and play a positive role in the bone resorption capacity of osteoclasts (Klejna, Naumnik, Gasowska, & Myśliwiec, 2009;Mary, Genevieve, Rachelle, Sells, & Merry, 2004). Currently, the commonly used indicators of reactive bone resorption are PICP and TRACP (Yao et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Zhao

Sun

2019

Animal Physiology Nutrition

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Hydroxyapatite, a mineral form of calcium (Ca) and phosphorus (P) that gives bones their rigidity, is the major and essential component of bones and teeth in the human and animal body. A suitable ratio of Ca and P is vital for bone growth. The aim of this study was to explore the effects of dietary calcium to available phosphorus ratios (Ca/AP) on bone metabolism and osteoclast activity of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) signalling pathway in piglets. At days 15 and 29, the piglets were assessed for growth performance, blood indicators, cytokines and the OPG/RANK/RANKL signalling pathway. Our results showed that piglets fed a dietary Ca/AP ratio of 2:1 increases growth performance and regulates blood indicators and cytokines (parathyroid hormone (PTH), calcitonin (CT), vitamin D3 (VD3), insulin‐like growth factor‐1 (IGF‐1), transforming growth factor‐β (TGF‐β), interleukin‐1 (IL‐1), interleukin‐6 (IL‐6), carboxyterminal propeptide of type I procollagen (PICP), tartrate‐resistant acid phosphatase (TRACP), alkaline phosphatase (ALP) and osteocalcin (OCN) content). We also demonstrated that this ratio affects hormone secretion and further bone metabolism through the OPG/RANK/RANKL signalling pathway of osteoclasts. These results indicate that a suitable dietary Ca/AP ratio is vital for bone growth and reduce the incidence of bone diseases such as osteoporosis, providing a practical basis for the raising of piglets.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Zhao

Sun

2019

Animal Physiology Nutrition

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“…The roles of OPG, RANKL and RANKL system in pathogenesis of osteodystrophy have been shown in many studies (24,25). It has been demonstrated that the OPG, RANKL and RANK system has an important role in vascular calcification and bone disorders by different mechanisms and mainly by cytokine misbalancing (22,26).…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that the OPG, RANKL and RANK system has an important role in vascular calcification and bone disorders by different mechanisms and mainly by cytokine misbalancing (22,26). Conflicting results have been described regarding prevention or the induction role of OPG for arterial calcification (24,27,28). Although OPG could primarily prevent arterial calcification, its secretion secondary to inflammatory processes could mediate an arterial calcification (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Osteoprotegerin (OPG) levels, total soluble receptor activator of nuclear factor-Kappa B ligand (total sRANKL) , and RANKL/OPG ratio in patients with rheumatoid arteritis

et al. 2017

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Background: Rheumatoid arthritis (RA) is one of most important collagen vascular diseases. It has an unknown origin. Objectives: The aim of this study was to evaluate circulating levels of osteoprotegerin (OPG), total soluble receptor activator of nuclear factor-Kappa B ligand (total sRANKL), and OPG/RANKL ratio in patients with RA. Methods: Forty-five females with RA, who fulfilled the American college of rheumatology (ACR) criteria for RA were included in this cross-sectional study. The overall disease activity was evaluated by the disease activity score based on 28 joint counts (DAS-28). The OPG and sRANKL were measured by the enzyme-linked immunosorbent assays (ELISA). The levels of high sensitive C-reactive protein (hsCRP) were measured by ELISA. We used Pearson's correlation for our comparisons. Results: There was no statistically significant difference between the levels of hsCRP, OPG, sRANKL and RANKL/OPG ratio in terms of DAS; 28 grades in our patients.No significant correlation was found between the serum levels of OPG and DAS-28 (P = 0.525), duration of the disease (P = 0.884), Z score of the femur (P = 0.546) and Z score of the spine (P = 0.492), T score of the femur (P = 0.137) and T score of the spine (P = 0.821) in the patient group. No significant correlations were found between sRANKL levels with DAS-28 (0.919), Z score of the femur (P = 0.971), Z score of the spine (P = 0.832) and T score of the femur (P = 0170) in the studied groups. Conclusions: Our study showed that there was no significant correlation between hsCRP, OPG, sRANKL and RANKL/OPG ratio in DAS-28 grading of our patients. For this reason they will not be used for evaluating disease activity. However, there was a significant difference between case and control groups except for sRANKL (pg/mL).

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“…Scale bar: 20 lm increase in pulp OPG levels in response to the up-regulation of RANKL and RANK in the uremic rats. In chronic dialysis patients, circulating OPG increases to reduce bone resorption, which acts as a protective mechanism in response to low bone mineral density (BMD) [2,30]. Furthermore, an in vitro study showed that cultured dental pulp cells express strong OPG and suppress osteoclasts, suggesting that pulp OPG suppresses tooth resorption [49], which may then lead to pulp osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Uremia Induces Dental Pulp Ossification but Reciprocally Inhibits Adjacent Alveolar Bone Osteogenesis

et al. 2015

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Uremic patients are predisposed to atrophy of the alveolar bone and narrowing of the dental pulp chamber. Such pulp chamber changes have only been diagnosed radiologically; however, this has not been supported by any pathological evidence. We used a uremic rat model with secondary hyperparathyroidism induced by 5/6 nephrectomy surgery and high-phosphate diet to examine the dental pulp and adjacent alveolar bone pathology. In addition, we collected pulp tissues for real-time PCR. We found an opposite histopathological presentation of the ossified dental pulp and the osteomalacic adjacent alveolar bone. Furthermore, pulp cells with positive staining for Thy-1, a surrogate stem cell marker, were significantly reduced in the pulp of uremic rats compared to the controls, indicating a paucity of stem cells. This was further evidenced by the reduced pulp expression of dickkopf-1 (Dkk-1), a Wnt/β-catenin signaling inhibitor produced by mesenchymal stem cells. In contrast, expressions of receptor activator of nuclear factor κB ligand (RANKL) and RANK in uremic pulp were up-regulated, probably to counteract the ossifying process of uremic pulp. In conclusion, uremic pulp ossifications were associated with a paucity of stem cells and dysregulated Dkk-1 and RANKL signaling systems, further shifting the imbalance toward osteogenesis. Strategies to counteract such an imbalance may offer a potential therapeutic target to improve dental health in uremic patients, which warrants further interventional studies.

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OPG/RANK/RANKL signaling system and its significance in nephrology.

Cited by 32 publications

References 56 publications

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG /RANK/RANKL signalling pathway in piglets

Osteoprotegerin (OPG) levels, total soluble receptor activator of nuclear factor-Kappa B ligand (total sRANKL) , and RANKL/OPG ratio in patients with rheumatoid arteritis

Uremia Induces Dental Pulp Ossification but Reciprocally Inhibits Adjacent Alveolar Bone Osteogenesis

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