Ophthalmic beta-blockers since timolol

Novack, Gary D.

doi:10.1016/0039-6257(87)90116-0

Cited by 108 publications

(45 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nipradilol sig nificantly inhibited the relaxations induced by the (3-adrenoceptor agonist in a concentra tion-related manner. Such a [3-adrcnoccptorblocking property of nipradilol may contrib ute to a reduction of intraocular pressure by topical application to patients with glaucoma [21]. (3-Adrenergic antagonists have been re ported to lower the intraocular pressure, prob Nipraditol-Induccd Retinal Arterial Relaxation ably by reducing the formation of aqueous humor [22,23], In anesthetized dogs, nipradilol caused a potent vasodilatation in the intraocular reti nal arterioles which was visualized by retinal fundus camera, videotape recorder, and a computerized digitizing system [11], This sys tem has the merit to show time-to-time altera tions in the diameter of retinal arterioles in vivo without any surgical invasion.…”

Section: Discussionmentioning

confidence: 99%

Canine Retinal Arterial and Arteriolar Dilatation Induced by Nipradilol, a Possible Glaucoma Therapeutic

Okamura¹,

Kitamura²,

Uchiyama³

et al. 1996

Pharmacology

View full text Add to dashboard Cite

The effects of nipradilol, an ocular hypotensive drug, on isolated canine retinal central arteries and on retinal arterioles in vivo were investigated. Nipradilol (10^–9 to 10^–5 mol/l) produced a dose-related relaxation of the arterial strips contracted with prostaglandin F_2α which was not influenced by timolol or indometacin. The median effective concentration of this drug was five times that of glycerol trinitrate (GTN). The nipradilol-induced relaxation in the endothelium-intact strips was not influenced by N^G-nitro-L-arginine, a nitric oxide synthase inhibitor, but was abolished by oxyhemoglobin and methylene blue. Treatment with high concentrations of sodium nitroprusside abolished the response to nipradilol, as observed with that to GTN. Retinal arterial strips responded to isoproterenol with a slight relaxation which was depressed by nipradilol. In anesthetized dogs, intra-arterial injections of nipradilol dilated the retinal arterioles in the ocular fundus; the dilator potency was approximately one fifth that of GTN. It is concluded that nipradilol dilates canine retinal arteries in vitro and arterioles in vivo, possibly due to activation of soluble guanylate cyclase and increased production of cyclic guanosine monophosphate that are associated with nitric oxide liberated from the molecule itself in the tissue but not derived from the endothelium and perivascular nerve. Beta adrenoceptor blocking action was determined in the retinal artery.

show abstract

Section: Discussionmentioning

confidence: 99%

Canine Retinal Arterial and Arteriolar Dilatation Induced by Nipradilol, a Possible Glaucoma Therapeutic

Okamura¹,

Kitamura²,

Uchiyama³

et al. 1996

Pharmacology

View full text Add to dashboard Cite

show abstract

“…We may therefore conclude with Novack [27] that 'the clinical importance of ISA in a topical agent is not entirely clear'.…”

Section: Discussionmentioning

confidence: 99%

“…The number of studies reporting on the in fluence of IOP-reducing drugs on visual func tion is surprisingly small [27] and controver sial. An improvement of visual function has been noted after acetazolamide [7,9,16,29], gangliosides [34] and the (3-blocker carteolol [10].…”

Section: Introductionmentioning

confidence: 99%

Pindolol and Timolol: Short-Term Influence on Angioscotomas and Static Brightness Contrast Sensitivity

Zulauf¹

1990

Ophthalmologica

View full text Add to dashboard Cite

In a double-masked, short-term study on 12 healthy elderly volunteers, angioscotomas and contrast sensitivities were measured 2 h after treatment with placebo, pindolol 1% and timolol 0.5%. In perimetry, angioscotomas did neither change in deepness nor in diameter significantly. However, the mean differential light sensitivity was highest with timolol (15.5 dB) and lower with pindolol (15.2 dB p < 0.018) and placebo (15.0 dB; p < 0.004). In contrast sensitivity testings, the mean contrast sensitivity was lowest with timolol (15.0 dB) and higher with pindolol (15.3 dB p < 0.001) and placebo (15.7 dB; p < 0.001). The differences between pindolol and placebo were not significant in both tests. The contrasting results may be explained by the locations where retinal sensitivity was tested, near or far from retinal vessels i.e. foveally or near the blind spot. Pharmacologically, the main difference between the two medications is the intrinsic sympathomimetic activity of pindolol.

show abstract

“…There have been many reports on the use fulness of ()-blockers in the treatment of pri mary glaucoma [1] and ocular hypertension [5], and it is considered that these drugs exert their effect of decreasing intraocular pressure by primarily suppressing the production of aque ous humor [6]. On the basis of this mechanism, fTblockers are considered to have potential as a drug for the therapy of secondary glaucoma.…”

Section: Discussionmentioning

confidence: 99%

“…There have been many reports on the hypo tensive effect of topical fl-blockers in the treat ment of primary glaucoma [1]; however, little work has been done on their clinical efficacy in secondary glaucoma [2][3][4], since the disease has diverse underlying diseases and pathologic states.…”

Section: Introductionmentioning

confidence: 99%

Hypotensive Effect of Carteolol on Intraocular Pressure Elevation and Secondary Glaucoma Associated with Endogenous Uveitis

Ohno¹,

Ichiishi²,

Matsuda³

1989

Ophthalmologica

View full text Add to dashboard Cite

The therapeutic effects of carteolol hydrochloride were evaluated in the treatment of 44 uveitis patients (51 eyes) with intraocular pressure elevation or secondary glaucoma. Carteolol ophthalmic solutions, either 1% or 2% were given twice day for more than 4 weeks in glaucomatocyclitic crisis and for more than 8 weeks in other forms of uveitis. Intraocular pressure significantly decreased from week 1 of treatment and persisted within normal limits until week 8 in glaucomatocyclitic crisis. Similarly, intraocular pressure decreased significantly from week 2 in other forms of uveitis. Intraocular pressure was well controlled in patients with open-angle glaucoma, but the control was insufficient in patients with angle-closure glaucoma. No adverse reactions such as systemic hemodynamic effects or exacerbations of intraocular inflammation were observed during this study. Carteolol therefore seems to be effective for the treatment of intraocular pressure elevation and secondary glaucoma associated with endogenous uveitis.

show abstract

Ophthalmic beta-blockers since timolol

Cited by 108 publications

References 144 publications

Canine Retinal Arterial and Arteriolar Dilatation Induced by Nipradilol, a Possible Glaucoma Therapeutic

Canine Retinal Arterial and Arteriolar Dilatation Induced by Nipradilol, a Possible Glaucoma Therapeutic

Pindolol and Timolol: Short-Term Influence on Angioscotomas and Static Brightness Contrast Sensitivity

Hypotensive Effect of Carteolol on Intraocular Pressure Elevation and Secondary Glaucoma Associated with Endogenous Uveitis

Contact Info

Product

Resources

About