Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job′s) syndrome: Case report and review of literature

Abstract

Hyperimmunoglobulinemia E (Job's) syndrome is characterized by markedly increased levels of immunoglobulin E, recurrent cutaneous and systemic pyogenic infections, atopic dermatitis, and peripheral eosinophilia. Although ocular involvement in Job's syndrome is rare, there are reports of keratoconus, staphylococcal chalazia with blepharitis, and Candida endophthalmitis by various authors. We present the first case report of retinal detachment with complicated cataract in Job's syndrome.

Do you know this syndrome?

“…1-5 This is an autosomal dominant disease, with sporadic cases detected, for which there is neither a predominant gender or race incidence. 1-5 …”

“…The most common functional defects in the host's immune system are the down-regulation of Tsuppressor cell function and neutrophil chemotaxis. 5,7 Therefore, patients with hyperimmunoglobulin E syndrome frequently present with cutaneous abscesses, impetigo, furunculosis, paronychia, cellulitis and recurrent Staphylococcus aureus pneumonias. Other causal agents of pulmonary infections are: Aspergillus spp e Pneumocystis jiroveci .…”

“…There is an association of this disease with the presence of scoliosis in adult patients and also with hyperextensibility of joints, occurring in 76 and 68% of the cases respectively. 5 …”

“…4,8 Ocular complications are infrequent, but might occur as keratoconus, staphylococcic chalazia with blepharitis and endophthalmitis, and other severe situations such as retinal detachment. 5 …”

Etiology and management of hyperimmunoglobulinemia E syndrome

“…[1] I am grateful for their contribution to ocular manifestations of hyperimmunoglobulinemia E (hyper-IgE) syndrome (formerly Job's syndrome). However, I would like to make some comments.…”