Ophthalmic Findings in Patients After Renal Transplantation

Berindán, K.; Nemes, Balázs; Szabó, Réka P.; Módis, László

doi:10.1016/j.transproceed.2017.06.016

Cited by 19 publications

(16 citation statements)

References 6 publications

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“…The mean age was 43±12.78 similar to a published report. 5 Some studies have reported the mean age of patients to be 53.4 years, 10 59±11 years, 11 which is higher than our finding. Less than 40 years are found to have fewer chances of progressing to ESRD.…”

Section: Discussioncontrasting

confidence: 78%

“…This may suggest that as the incidence of steroid-related cataracts increases the chances of steroid-induced glaucoma also increases. Published article has reported 5% glaucoma among all renal transplant patients, 10 whereas others did not find any cases of glaucoma in their study. 5 Only 1.4% of patients had increased IOP in a published study.…”

Section: Discussionmentioning

confidence: 69%

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Cataract among Patients with Renal Transplantation in a Tertiary Care Centre: A Descriptive Cross-sectional Study

et al. 2023

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Introduction: Intensive immunosuppressant therapy after renal transplantation has found to cause systemic and ocular side effects among them is cataracts. Studies on a similar topic have still remained explored in our setting. The aim of the study was to find out the prevalence of cataract among patients with renal transplantation in a tertiary care centre. Methods: This descriptive cross-sectional study was conducted among patients of renal transplantation at tertiary care centres from 1 May 2021 to 31 October 2021. The data was collected after the ethical approval from Institutional Review Committee [Reference number: 397(6-11) e2077/078]. Study proforma recorded the number of patients with cataracts, duration of steroid use, mean age and other comorbidities. A convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated. Results: Out of 31 renal transplant patients, 10 (32.26%) (15.80-48.72, 95% Confidence Interval) had cataract. Conclusions: The prevalence of cataract among renal transplantation patients was found to be lower than similar studies done in similar settings.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 69%

Cataract among Patients with Renal Transplantation in a Tertiary Care Centre: A Descriptive Cross-sectional Study

et al. 2023

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“…126 There are no robust OCT studies in renal transplant recipients, but the available data suggest that retinopathy and nerve fiber layer thinning are common. 127 CVD outcomes. Studies linking OCT-derived metrics to prevalent CVD are beginning to emerge.…”

Section: The Chorioretinal Circulation: Cvd Risk Factors and Outcomesmentioning

confidence: 99%

“… 126 There are no robust OCT studies in renal transplant recipients, but the available data suggest that retinopathy and nerve fiber layer thinning are common. 127 …”

Section: Retinal Imaging the Kidney And Cvdmentioning

confidence: 99%

The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

Farrah

Dhillon

Keane

et al. 2020

Kidney International

105

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Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and their associated cardiovascular disease. Homology between the eye and the kidney suggests that noninvasive imaging of the retinal vessels can detect these microvascular alterations to improve targeting of at-risk patients. Retinal vessel–derived metrics predict incident hypertension, diabetes, CKD, and cardiovascular disease and add to the current renal and cardiovascular risk stratification tools. The advent of optical coherence tomography (OCT) has transformed retinal imaging by capturing the chorioretinal microcirculation and its dependent tissue with near-histological resolution. In hypertension, diabetes, and CKD, OCT has revealed vessel remodeling and chorioretinal thinning. Clinical and preclinical OCT has linked retinal microvascular pathology to circulating and histological markers of injury in the kidney. The advent of OCT angiography allows contrast-free visualization of intraretinal capillary networks to potentially detect early incipient microvascular disease. Combining OCT’s deep imaging with the analytical power of deep learning represents the next frontier in defining what the eye can reveal about the kidney and broader cardiovascular health.

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“…Moreover, in patients after KTx one can see the progress of a slow optic nerve neuropathy, that is, a decrease in retinal nerve fiber layer (RNFL) thickness. [ 9 ] Persons after KTx are also more prone to cataracts. Risk factors predisposing to cataract development after KTx include: age, diabetes, HD, and use of large doses of steroids.…”

Section: Introductionmentioning

confidence: 99%

A 10-year monitoring of the eyesight in patients after kidney transplantation

Raczyńska

Ślizień²,

Bzoma

et al. 2018

Medicine

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A pilot study of a 10-year analysis of the eyesight characteristics in patients after renal transplantation with a view to a later wider study of the same population.The study encompassed 50 eyes in 25 patients who underwent renal transplantation in the years 2007 and 2008. All patients underwent: visual acuity measurement, tonometry, slit lamp examination, and spectroscopic optical coherence tomography.Changes in the eyes observed during the 10-year observation period included mostly: cataract (48%), hypertensive angiopathy (28%), diabetic macular edema (16%), and glaucoma (16%). Ten years after the renal transplant visual acuity declined in 15 patients (60%). In 67% of those with eyesight deterioration the cause was cataract, while in patients with no changes in the eyesight (n = 10) cataract was diagnosed only in one. Patients with cataracts had been more often treated with cyclosporine, and that difference was statistically significant (73% vs 21%; P < .05). Comparing patients with hypertensive angiopathy with controls has shown that in the first group creatinine levels were statistically significantly higher (1.6 vs 1.16 mg/dL; P < .05). Patients with angiopathy had been also longer on renal replacement therapy before transplant (57 vs 26 months, P > .05), and this group included also statistically more persons after retransplantation (43% vs 5%, P < .05).Most frequent ophthalmological diagnoses in patients after a kidney transplant include cataract, diabetic retinopathy, and hypertensive angiopathy. Visual acuity deterioration was seen in 60% of patients and was mainly the effect of cataract progress. The effect of cyclosporine on cataract progress was significant. The diagnosis of hypertensive angiopathy corresponded with poorer function of the transplanted kidney.

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Ophthalmic Findings in Patients After Renal Transplantation

Cited by 19 publications

References 6 publications

Cataract among Patients with Renal Transplantation in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Cataract among Patients with Renal Transplantation in a Tertiary Care Centre: A Descriptive Cross-sectional Study

The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

A 10-year monitoring of the eyesight in patients after kidney transplantation

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