Ophthalmic Manifestations of Metastatic Breast Cancer

Bullock, John D.; Yanes, B.

doi:10.1016/s0161-6420(80)35124-5

Cited by 71 publications

(21 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We confirmed that in 60% of cases there is a history of primary tumor, especially in mammary gland tumors (38); in 30% of cases even a complete medical history of the patient does not reveal the existence of a primary tumor (12). We should consider that metastases may simulate other non-malignant injuries such as hemangiomas, myositis, thyroid orbitopathy and other inflammatory processes.…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Metástasis orbitarias: Serie de cuatro casos y revisión de la literatura

González

López

2006

Arch Soc Esp Oftalmol

View full text Add to dashboard Cite

Objective: To report four cases of orbital metastases and review the literature related to this condition. Methods:We reviewed the clinical records of the four patients and the appropriate world literature. Results: Two women 51 and 82 years old presented with orbital metastases from a primary breast tumour and a third woman (45 years old) had orbital metastases from a primary lung tumour. One man 60 years old presented with a metastases from a renal tumour. Two patients, one with breast metastases and the one with lung metastases, died of their disease. The remaining two patients are still alive with stable disease at the time of writing this report. Conclusion:The metastases in our series originated from tumours that frequently produce orbital metastases-the breast, lung and kidney. The clinical characteristics of the orbital syndromes they caused were similar to those reported in the literature. The clinical presentation was torpid in three cases and had a fulminating course in the ORIGINAL ARTICLE RESUMEN Objetivo: Describir cuatro casos clínicos de metás-tasis orbitarias y hacer una revisión de la literatura sobre esta patología. Métodos: Revisión de historias clínicas y de la bibliografía. Resultados: Dos mujeres de 51 y 82 años de edad presentaron una metástasis orbitaria procedente de un tumor de mama y una tercera (45 años de edad) de una neoplasia pulmonar. Un paciente varón de 60 años de edad presentó una metástasis orbitaria procedente de un tumor renal. Dos de los pacientes, una paciente con metástasis de tumor de mama y la paciente con metás-tasis de tumor pulmonar, fallecieron a consecuencia de su tumor primario, la primera a los dos años y medio y la segunda dos meses después de los primeros signos de metástasis orbitaria. Los otros dos pacientes continúan vivos en situación estable. Conclusiones: Las metástasis en nuestra serie se originaron en tumores de mama, pulmón y riñón, que se encuentran entre los tumores que con más frecuencia producen metástasis orbitarias. Las características clínicas del síndrome orbitario coin-452 ARCH SOC ESP OFTALMOL 2006; 81: 451-462 GONZÁLEZ F, et al.

show abstract

Section: Discussionsupporting

confidence: 62%

“…High levels of carcinoembryonic antigens in the plasma reveal the existence of metastasis, although a negative result may not reveal its absence (38). In prostate cancer, alkaline phosphatase is high and seminomas produce human chorionic gonadotropin.…”

Section: Discussionmentioning

confidence: 99%

Metástasis orbitarias: Serie de cuatro casos y revisión de la literatura

González

López

2006

Arch Soc Esp Oftalmol

View full text Add to dashboard Cite

show abstract

“…1 The incidence of ocular metastases among patients with breast carcinoma in clinical series has been reported to vary between 8 and 10%. 2,3 The occurrence of ocular metastases may not be appreciated because of the dominant clinical picture of metastases in other organs.…”

Section: Introductionmentioning

confidence: 99%

Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma

Fenton

Kemp

Harnett

2004

Eye

View full text Add to dashboard Cite

Background Breast carcinoma metastasises to the eye more frequently than is clinically recognised. The incidence is perhaps not appreciated, either because of the more common involvement and consequences of spread to major organs (such as lung, liver, or bone) or because a number of eye lesions are small and asymptomatic. Over a 6-month period, all patients with locally advanced or metastatic breast cancer were screened for ocular involvement and as a result management recommendations made. Materials and methods Between January 2001 and June 2001, 68 patients with known locally advanced or metastatic breast carcinoma were referred for a screening ophthalmic examination. The aim of the study was to assess the frequency of asymptomatic ocular metastases by breast carcinoma in visually asymptomatic patients. The recognition and early treatment of both ocular metastases and ocular manifestations of metastatic breast carcinoma are important in maximising the quality of life in this group of palliative patients. These patients were all referred and recruited from the Beatson Oncology Centre and Breast Unit at the Western Infirmary, Glasgow by the oncologist (ANH). Examination included visual acuity assessment, slit-lamp examination, tonometry, and indirect ophthalmoscopy. Results The median time from diagnosis of breast carcinoma to ophthalmic screening was 5 years (range 6 months-23 years). No patient had any evidence of choroidal metastases on ophthalmic examination. Four patients (5.8%) had ophthalmic manifestations of metastatic breast carcinoma and a further two had ocular

show abstract

“…The prevalence of metastases to the ocular region in patients with known disseminated cancer ranges from as low as 0.07 to as high as 27% [3, 4]. The possible increase in incidence in the last decades may reflect the longer survival of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Treatment Options in the Management of Choroidal Metastases

Amer¹,

Pe’er²,

Chowers³

et al. 2004

Ophthalmologica

View full text Add to dashboard Cite

We performed a retrospective study of 40 consecutive patients (50 eyes) treated for choroidal metastases of solid systemic malignancies in order to evaluate treatment results. Patients received either systemic or local therapy or a combination of both. The most common primary tumor was breast carcinoma (62.5%). Systemic chemotherapy alone was used in 13.3% of eyes, local therapy alone in 44.4%, and a combination of both in 42.2% of eyes. Local treatment modalities included brachytherapy, external beam irradiation, and laser photocoagulation. Complete regression of the choroidal metastases was seen in 57.8% of eyes, partial regression in 15.6 and no response in 4.4%; 22.2% were not available for re-evaluation. We have concluded that the treatment modality in patients with metastatic ocular disease should be individually tailored. When ocular metastases are concurrent with widespread metastatic disease, systemic chemotherapy alone or in combination with local therapy is reasonable. In patients manifesting metastases in the eyes alone, local therapy modalities may be safe, allowing conservation of visual functions with minimal systemic morbidity.

show abstract

Ophthalmic Manifestations of Metastatic Breast Cancer

Cited by 71 publications

References 17 publications

Metástasis orbitarias: Serie de cuatro casos y revisión de la literatura

Metástasis orbitarias: Serie de cuatro casos y revisión de la literatura

Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma

Treatment Options in the Management of Choroidal Metastases

Contact Info

Product

Resources

About