Ophthalmic presentation of relapsed HTLV1- associated adult T-cell leukaemia lymphoma (ATLL) in a Trinidadian man

Charles, K. S.; Leelah, Niall; Murray, D C

doi:10.1177/0049475514522459

Cited by 2 publications

(2 citation statements)

References 8 publications

(10 reference statements)

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“…To the remaining 78 articles, we added 12 obtained in ATL references in books and papers. Finally, 90 articles were chosen including 940 ATL reported cases; 24 papers were found in the Caribbean, 15,24,25,28–48 two in Central America (Table 2) 49,50 and 64 in South America (Table 3). 9,16,51…”

Section: Resultsmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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Adult T-cell leukemia/lymphoma (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1) which is endemic in countries of Caribbean and Central and South America. We performed a systematic search and review to identify publications on ATL in these countries to verify if this disease was getting recognition in these regions as well as the characteristics of the observed cases. The median age of 49.4 years was lower than that referred to in Japan. According to our findings in most Brazilian states and in some other countries, ATL is not being recognized and should be strongly considered in the differential diagnosis of T-cell leukemias/lymphomas. Failure to identify these cases may be due to the unsystematic realization of serology for HTLV-1 and phenotypic identification of non-Hodgkin lymphomas that may result from lack of resources. Detection of ATL cases has been more feasible with cooperation from foreign research centers. A huge effort should be made to improve the surveillance system for ATL diagnosis in most of the South- and Central-American and Caribbean countries, and this attitude should be embraced by public organs to support health professionals in this important task.

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Section: Resultsmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

2016

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“…Since the first report in the ophthalmic literature by Kabayama et al, most data on ocular adnexal and orbital ATLL have been documented in isolated case reports. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] The absence of cohesive data on the orbital and ocular adnexal manifestations of this rare and aggressive disease can limit its appropriate work-up, timely diagnosis, and appropriate management. Herein, we describe a 20-year-old man with orbital involvement by ATLL as an initial manifestation of his systemic disease and review the presentation, evolving diagnostic modalities, current management trends, and outcomes for all well-documented cases of orbital and ocular adnexal ATLL.…”

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confidence: 99%

Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review

Henry

Bagg

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe a patient with orbital adult T-cell leukemia/lymphoma (ATLL) and to review the literature on presentation, diagnostics, management, and clinical course of this rare disease. Methods: A systematic literature review. PubMed/MEDLINE and Google Scholar databases were searched for all well-documented cases of orbital/ocular adnexal ATLL. Results: Sixteen patients were included in the final analysis. The median age at diagnosis was 47 years (range, 20–85), 9/16 patients (56%) were male, and patients were of Japanese (10/16, 63%), Caribbean (5/16, 31%), or African (1/16, 6%) origin. Proptosis (6/15, 40%) and visual loss (5/15, 33%) were the most common presenting signs. Involvement of adjacent structures was documented in 8 of 16 (50%) patients. All patients had evidence of systemic ATLL, which was identified concurrently with orbital/ocular adnexal disease in 9 of 15 (60%) patients. Management included multi-agent chemotherapy with steroids (9/13, 69%), antivirals (2/13, 15%), biologic agents (4/13, 31%), and umbilical cord blood transplantation (1/13, 8%). Most patients (8/12, 67%) experienced at least partial remission with disease relapse occurring in 6 of 8 patients (75%). The median survival time was 28 months (95% CI, 5.5–50.5 months). Conclusions: Adult T-cell leukemia/lymphoma should be considered in the differential diagnosis of orbital and ocular adnexal space-occupying lesions, particularly in male patients from endemic regions. Orbital disease is frequently locally aggressive and presents concurrently with systemic ATLL, highlighting the importance of comprehensive multimodal work-up and multidisciplinary management. Emerging targeted therapies and hematopoietic stem cell transplant may prolong survival.

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Ophthalmic presentation of relapsed HTLV1- associated adult T-cell leukaemia lymphoma (ATLL) in a Trinidadian man

Cited by 2 publications

References 8 publications

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Adult T-cell leukemia/lymphoma in South and Central America and the Caribbean: systematic search and review

Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review

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