Ophthalmic Sensors and Drug Delivery

Savariraj, A. Dennyson; Salih, Ahmed E.; Alam, Fahad; Elsherif, Mohamed; AlQattan, Bader; Khan, Ammar Ahmed; Yetisen, Ali K.; Butt, Haider

doi:10.1021/acssensors.1c00370

Cited by 44 publications

(29 citation statements)

References 243 publications

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“…These inbuilt channels or chambers can be employed to load drugs/mRNA/stem cells for promising personalized therapeutic applications. [ 29,54 ] More sophisticated SCL wearable platforms are expected in the future, such as a medical bandage SCL that can simultaneously include biosensing, drug delivery, and electrical stimulation.…”

Section: Outlooks Opportunities and Challengesmentioning

confidence: 99%

“…To solve these shortcomings, the SCL‐based drug delivery wearable platform has been devised and developed. [ 27–29 ] SCL‐based drug delivery systems are designed to achieve efficient drug encapsulation, accurate drug dose delivery, sustained drug release, adequate drug bioavailability, and better patient compliance. [ 25,29 ] As a very recent example, the first clinical trial investigating LLT‐BMT1, a drug‐eluting SCL product from MediPrint Ophthalmics, has been shown to be safe and well‐tolerable for the treatment of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

“…[ 27–29 ] SCL‐based drug delivery systems are designed to achieve efficient drug encapsulation, accurate drug dose delivery, sustained drug release, adequate drug bioavailability, and better patient compliance. [ 25,29 ] As a very recent example, the first clinical trial investigating LLT‐BMT1, a drug‐eluting SCL product from MediPrint Ophthalmics, has been shown to be safe and well‐tolerable for the treatment of glaucoma. These uplifting trial results will undoubtedly boost the advances in CL products for patients suffering from conceivably‐disabling ocular diseases such as glaucoma and diabetic retinopathy.…”

Section: Introductionmentioning

confidence: 99%

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Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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Section: Outlooks Opportunities and Challengesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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“…This is particularly relevant when a contact lens is coupled with drug compartments for on-demand delivery. The blend of a multiple-analyte sensor and a feedback-based drug delivery system that act in an automated manner can revolutionize personalized points of care [ 145 ]. Artificial intelligence can be a valuable addition to the study of the therapeutic effects of these smart devices, while machine learning algorithms can provide long-term monitoring of an individual’s health status, thus further improving the course of treatment [ 146 ].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

et al. 2022

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In recent years, wearable contact lenses for medical applications have attracted significant attention, as they enable continuous real-time recording of physiological information via active and noninvasive measurements. These devices play a vital role in continuous monitoring of intraocular pressure (IOP), noninvasive glucose monitoring in diabetes patients, drug delivery for the treatment of ocular illnesses, and colorblindness treatment. In specific, this class of medical devices is rapidly advancing in the area of drug loading and ocular drug release through incorporation of electrospun fibers. The electrospun fiber matrices offer a high surface area, controlled morphology, wettability, biocompatibility, and tunable porosity, which are highly desirable for controlled drug release. This article provides an overview of the advances of contact lens devices in medical applications with a focus on four main applications of these soft wearable devices: (i) IOP measurement and monitoring, (ii) glucose detection, (iii) ocular drug delivery, and (iv) colorblindness treatment. For each category and application, significant challenges and shortcomings of the current devices are thoroughly discussed, and new areas of opportunity are suggested. We also emphasize the role of electrospun fibers, their fabrication methods along with their characteristics, and the integration of diverse fiber types within the structure of the wearable contact lenses for efficient drug loading, in addition to controlled and sustained drug release. This review article also presents relevant statistics on the evolution of medical contact lenses over the last two decades, their strengths, and the future avenues for making the essential transition from clinical trials to real-world applications.

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“…In recent years, the adoption rate of wearable electronics has begun to surge from its prototypical infancy in the early part of the last decade. The demand for such devices is driven by, but not limited to, the increasing desire for continuous health monitoring, 1–4 controlled delivery of nanomedicines, 5–7 advancement of soft robotics, 8–12 and physically immersive virtual/augmented reality products 13–15 . A limitation that these diverse technologies all have in common is the constraints set by current rigid electronics that force their soft environments to conform around them.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional liquid metal polymer composites

Guymon

Malakooti

2022

Journal of Polymer Science

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Liquid metal polymer composites are an emerging class of functional materials with potentially transformative impacts in wearable electronics, soft robotics, and human-computer interactions. By employing different processing methods, room temperature liquid metal inclusions can be embedded in insulating polymers like elastomers to incorporate functional properties of metals while the matrix remains soft and stretchable. These solid-liquid composites offer an interesting, yet complex multifunctional material system. In this review, we present an exclusive overview of the synthesis methods, structural and functional properties, and applications of gallium-based liquid metal polymer composites. Common methods to control the size of liquid metal inclusions and their interaction in polymers are discussed. Moreover, the effect of liquid metal microstructures on the overall properties of the composites is summarized. We also highlight the new trends in terms of material composition, printing process, and novel applications of liquid metal polymer composites in intelligent systems.

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Ophthalmic Sensors and Drug Delivery

Cited by 44 publications

References 243 publications

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

Multifunctional liquid metal polymer composites

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