Ophthalmo-Neurological Symptoms in Connection With Malignant Nasopharyngeal Tumours

Abstract

Jans Nielsen) and Aarhus (Professor C. Krebs). MR. CHAIRMAN, Ladies and Gentlemen, I feel greatly pleased and honoured to be allowed to speak before this dignified-audience and thus to re-establish the connection between British and Danish ophthalmology, a connection which was previously so intimate and profitable. Danish ophthalmologists, among whom the best known are Bjerrum, Tscherning, Edmund Jensen, Heerfordt, Lundsgaard, and Roenne, are greatly indebted to British ophthalmologists, whose best known representatives with us are men like Young, M1ackenzie, Bowman, Priestley-Smith, Marcus Gunn and Duke-Elder. During the gloomy years of German occupation Dani-sh ophthalmology greatly missed the inspiration from British ophthalmology. Now that I stand here as the first Danish speaker after the war I

Nasopharyngeal Carcinoma: An Account of the Cranial Nerve Lesions Found in 185 Cases

“…Woltman (1922) quoted the same two nerves but in reversed order of frequency. Jefferson (1953) found the fifth nerve to be most commonly involved while Simmons and Ariel Godtfredsen (1947) collected 454 cases of malignant disease of the nasopharynx from (1949) quote the order as sixth, twelfth, fifth. All authorities are in agreement that the olfactory and auditory nerves are seldom involved but that anosmia is due to nasal obstruction and deafness to blockage of the Eustachian tube.…”

Neurological complications in two children with Lemierre syndrome

“…2,7 Combined involvement of 6th and 12th cranial nerves is unusual and is a known feature of the so-called 'clival syndrome', wherein the 6th to 12th cranial nerves are affected by various lesions as they pass along the clival margin. This entity was originally described by Godtfredsen 10 in 1947 in patients …”

Eye twist and tongue twist: a rare neurological syndrome

“…It was Godtfredsen who first described this combination in cases of nasopharyngeal carcinoma, where he emphasised that, the findings of sixth CN paresis with twelfth CN paresis are not by a chance. There was also occurrence of trigeminal neuralgia in majority of such cases 2. This combination, when caused by nasopharyngeal carcinoma, is described as Godtfredsen syndrome 3.…”

“…In an attempt to describe the involvement of relatively separated sixth and twelfth CNs without other distal CNs involvement, Godtfredsen attributed sixth CN palsy to direct invasion of the tumour around the cavernous sinus and twelfth CN to the retropharyngeal lymphnode metastasis causing nerve dysfunction at hypoglossal canal, as all of the patients had cervical lymphadenopathy 2. The anterior exiting nature of these two nerves is attributed to the involvement by clivus tumour which can describe our patient’s condition, sixth nerve being compressed at Dorello’s canal by the clival mass.…”