Ophthalmological Approach for the Diagnosis of Dry Eye Disease in Patients with Sjögren’s Syndrome

Barrientos, Robinson T.; Godín, Fernando; Rocha‐de‐Lossada, Carlos; Soifer, Matias; Sánchez‐González, José‐María; Moreno-Toral, Esteban; González, Ana-Luisa; Zein, Mike; Larco, Pablo; Mercado, Carolina; Piedrahita, Maria-Adelaida

doi:10.3390/life12111899

Cited by 10 publications

(8 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies on Sjogren syndrome and Rheumatoid arthritis reported the prevalence of dry eye about 23 per 1000 person-years. 10,11 MS disease pathogenesis has integral parts of the inflammatory cytokines secreted by Th1 and Th17, resulting in increased blood-brain barrier permeability to monocytes and macrophages. Th1 cells are found in damaged parts of the CNS and are actively present in MS patients' bloodstream, which produces inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study

Sorkhabi,

Khavandi,

Ayromlou

et al. 2024

J Res Clin Med

View full text Add to dashboard Cite

Introduction: Demyelination of the nerve fibers of the central nervous system is a main pathology of multiple sclerosis (MS), in which inflammation plays a major role. Studies have shown that inflammation is the leading cause of dry eye disorder. To investigate the association between inflammation and both diseases, we aimed to estimate the prevalence of dry eye syndrome (DES) in MS patients and its correlation with the severity of the disease and disability status. Methods: We enrolled 100 MS patients randomly and 100 healthy controls. DES was evaluated by Dry Eye questionnaire and Scoring System (DESS), tear break-up time (TBUT), tear meniscus height (TMH), and Schirmer 1 & 2 tests in subjects. Furthermore, the leading disability in MS was assessed by a clinician (neurology professor) using the related questionnaire (Expanded Disability Status Scale). Results: According to the TBUT, THM, and Schirmer tests, the number of subjects with abnormal results was significantly higher in the MS group than in the control group. The severity of DES measured by the DESS was also higher in the MS group compared to control group. Also, there was a significant relationship between increasing disability and abnormal dry eye tests, especially in MS patients with EDSS scores>4. Conclusion: The present study highlights the importance of considering dry eye disorder in MS patients as a possible consequence of inflammation. Also, our results suggested a significant relationship between dry eye disorder and the EDSS scores.

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study

Sorkhabi,

Khavandi,

Ayromlou

et al. 2024

J Res Clin Med

View full text Add to dashboard Cite

show abstract

“…Moreover, the present non-invasive diagnostic methods lack the necessary specificity and sensitivity, resulting in SS diagnosis involving invasive gland biopsy and functional assessments [44]. As a result, many have researched alternative non-invasive and disease-specific diagnostic tools to provide a quicker diagnostic while enabling treatment monitoring [41,45].…”

Section: Novel Diagnostic Methodsmentioning

confidence: 99%

“…In short, innovative diagnostic methodologies have emerged, holding transformative potential for the timely, non-invasive, and accurate diagnosis of SS. Thanks to advances like immunoaffinity mass spectrometry, the analysis of serum, saliva, and tear proteomics has become more accessible, permitting accurate quantification of specific proteins implicated in SS [45]. Unveiling the underlying pathways and proteins in SS pathogenesis has led to the identification of promising biomarkers, including CXCL10, MUC5AC, the JAK-STAT signaling pathway, MMP-9, and miRNA derived from exosomes.…”

Section: Barriers To Clinical Translation: the Gap Between Innovation...mentioning

confidence: 99%

Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms

Wu,

Serhan,

Faucher

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Sjögren’s syndrome dry eye (SSDE) is a subset of Sjögren’s syndrome marked by dry eye symptoms that is distinct from non-Sjögren’s syndrome dry eye (NSSDE). As SSDE can lead to severe complications, its early detection is imperative. However, the differentiation between SSDE and NSSDE remains challenging due to overlapping clinical manifestations. This review endeavors to give a concise overview of the classification, pathophysiology, clinical features and presentation, ocular and systemic complications, clinical diagnosis, and management of SSDE. Despite advancements, limitations in current diagnostic methods underscore the need for novel diagnostic modalities. Thus, the current review examines various diagnostic biomarkers utilized for SSDE identification, encompassing serum, salivary, and tear analyses. Recent advancements in proteomic research and exosomal biomarkers offer promising diagnostic potential. Through a comprehensive literature review spanning from 2016 to 2023, we highlight molecular insights and advanced diagnostic modalities that have the potential to enhance our understanding and diagnosis of SSDE.

show abstract

“…The constellation of autoantibodies (particularly antinuclear anti-Ro/SS-A and anti-La/SS-B) indicates a loss of B cell tolerance along with dysregulated activity in the interleukin (IL)-1 system. The disease has detrimental clinical, quality-of-life, and financial burdens on patients [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Targets in the Management of Dry Eye Disease Associated with Sjögren’s Syndrome: An Updated Review of Current Insights and Future Perspectives

Almulhim

2024

JCM

View full text Add to dashboard Cite

Dry eye disease (DED) is a continuing medical challenge, further worsened in the autoimmune inflammatory hyperactivation milieu of Sjögren’s syndrome (SS) due to disturbances to innate and adaptive immunity with malfunctioning neuro-endocrine control. However, the pathogenetic mechanisms of SS DED are not fully established. This review summarized the available evidence, from systematic reviews, meta-analyses, and randomized clinical trials, for the efficacy and safety of the available ocular therapeutics for the management of SS DED. Relevant studies were obtained from major databases using appropriate keywords. The available largely empirical symptomatic, supportive, and restorative treatments have significant limitations as they do not alter local and systemic disease progression. Topical therapies have expanded to include biologics, surgical approaches, scleral lens fitting, the management of lid margin disease, systemic treatments, nutritional support, and the transplantation of stem cells. They are not curative, as they cannot permanently restore the ocular surface’s homeostasis. These approaches are efficacious in the short term in most studies, with more significant variability in outcome measures among studies in the long term. This review offers an interdisciplinary perspective that enriches our understanding of SS DED. This updated review addresses current knowledge gaps and identifies promising areas for future research to overcome this medical challenge.

show abstract

Ophthalmological Approach for the Diagnosis of Dry Eye Disease in Patients with Sjögren’s Syndrome

Cited by 10 publications

References 90 publications

Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study

Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study

Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms

Therapeutic Targets in the Management of Dry Eye Disease Associated with Sjögren’s Syndrome: An Updated Review of Current Insights and Future Perspectives

Contact Info

Product

Resources

About