Ophthalmological manifestations of systemic autoimmune diseases

Kutija, Marija Barišić

doi:10.1016/b978-0-323-85389-7.00008-9

Cited by 1 publication

(1 citation statement)

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“…The use of other mainstay therapeutics included methotrexate, azathioprine, sulfasalazine, hydroxychloroquine, D-penicillamine, and mycophenolate; however, the clinical application of these drugs was rarely adequately defined in terms of immune specificity or, in fact, in terms of the underlying pathogenesis of disease (Kutija, 2023). Because there was a high risk of adverse events, these agents were employed one after the other or in combination with extreme caution.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Approaches to Immunotherapy Induced Chronic Inflammatory Diseases

Adebanjo,

Bakare,

Matthew

et al. 2024

JSMT

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The development of immunotherapy vaccines hinges on the identification of suitable biomarkers and the optimization of treatment combinations to enhance their efficacy in patients. Over the past few decades, research on immunotherapy vaccines has advanced, leading to the availability of numerous defined vaccinations. Still unsolved are a few issues, such as appropriate tumor antigen, adjuvant components for chronic inflammatory diseases, appropriate delivery mechanisms, and efficient strategies to fend off immunological attacks. The term chronic inflammatory diseases (CID) refers to a group of illnesses in which the immune system is unable to control typical acute inflammation, resulting in an ongoing, unresolved state of inflammation. Conditions including psoriasis, inflammatory bowel disease, and rheumatoid arthritis affect a considerable number of people globally, making the CID a substantial burden on global healthcare systems. Conventional therapies frequently relieve symptoms, but they may also have serious adverse effects and be ineffective. By focusing on the dysregulated immune responses that underlie chronic inflammatory illnesses, immunotherapy has become a viable treatment option. With a focus on important therapeutic approaches, mechanisms of action, clinical efficacy, and safety profiles, this research paper offers an extensive assessment of immunotherapy-induced treatments for chronic inflammatory illnesses. Furthermore, the paper addresses the present CID conundrums and potential paths forward in the creation and enhancement of immunotherapeutic treatments for the crippling ailments.

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Section: Introductionmentioning

confidence: 99%