Ophthalmological study of epidemic dropsy.

Abstract

An ophthalmological study of a series of cases of epidemic dropsy in a recent outbreak in Madhya Pradesh was carried out. The present communication reports superficial retinal haemorrhages in epidemic dropsy, an observation believed not to have been previously reported.

Induction of contracture and extracellular Ca2+ influx in cardiac muscle by sanguinarine: a study on cardiotoxicity of sanguinarine

“…Upreti et al [11] reported that cardiac muscle fibers showed degenerative changes by treating Argemone mexicana seed oil orally in rat. And in some extreme cases, sanguinarine poisoning can cause glaucoma and death due to cardiac arrest [15]. The positive inotropic action of SANG observed in this study is compatible with the previous report from Seifen et al [4] and is possibly due to the inhibition of Na,K-ATPase.…”

“…The clinical syndromes of argemone oil poisoning include tachycardia, gallop rhythm, hepatomegaly, diarrhea, nausea, erythema, pitting edema, and breathlessness, etc. In some extreme cases, sanguinarine poisoning can cause glaucoma and death due to cardiac arrest [15]. The mechanism leading to cardiac arrest has not been resolved.…”

Epidemic dropsy 2013: case series

“…Raised intraocular pressure is noticed in 0-12% of cases and retinal haemorrhage if present, requires urgent surgical intervention to prevent blindness, but it was not seen in any of the patients in this case series. 12,13 Cardiac and renal failure usually signify a poor prognosis: both were noted in our first two patients. Mortality is around 5%.…”