Ophthalmology manifestations of pediatric cancer treatment

Salvin, Jonathan; Hendricks, Dorothy

doi:10.1097/icu.0b013e328356230f

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…These dysfunctions occurred within the year after the end of the therapy, and subsequently disappeared or improved in all cases 99. In terms of vincristine use in the NBL chemotherapy, optic neuropathy, ptosis, lagophthalmos, and corneal hypoesthesia were observed as side effects 100. Furthermore, procedures, such as catheter insertion because of the NBL treatment, may also be associated with ophthalmologic disorders, primarily HS 101.…”

Section: Discussionmentioning

confidence: 99%

“…99 In terms of vincristine use in the NBL chemotherapy, optic neuropathy, ptosis, lagophthalmos, and corneal hypoesthesia were observed as side effects. 100 Furthermore, procedures, such as catheter insertion because of the NBL treatment, may also be associated with ophthalmologic disorders, primarily HS. 101 In the previous research, we observed that the surgical treatment of the NBL resulted in ptosis and miosis more frequently than the disease itself.…”

Section: Clinical Image Of Patients With the Opsoclonus-myoclonus Syn...mentioning

confidence: 99%

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Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review

Kuchalska

Derwich²,

Gotz‐Więckowska

2022

Journal of Pediatric Hematology/Oncology

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Neuroblastoma (NBL) is the most common extracranial solid tumor found in pediatric patients. It develops from the sympathetic tract tissue. Although the symptoms are associated with tumor localization, sometimes NBL is manifested as ophthalmologic disorders. In this paper, we describe their incidence and the correlation with the prognosis. We searched 2 databases (PubMed and Web of Science) for papers published before April 2022, and concerned pediatric patients with NBL, which caused ophthalmologic changes. We collected 7 papers assessing the occurrence of ophthalmologic findings in the NBL patients, as well as 68 case reports presenting children with orbital changes and NBL, or with other tumors stemming from the sympathetic ganglia. The statistical analysis was performed to synthetize the data. The ophthalmologic signs occurred in 17.89% of the NBL cases; however, they were observed on presentation in 10.68%. The isolated ocular presentation was found in 2.56% of patients, whereas Horner syndrome was most frequent. The ophthalmologic symptoms correlated with patients’ age, primary tumor site, and survival rate. NBL may be challenging to diagnose in cases with isolated ophthalmologic manifestations. Numerous possible ocular signs can be observed, which emphasize the need for multidisciplinary care with regard to the NBL patients.

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Section: Discussionmentioning

confidence: 99%