Opiate analgesia: Evidence for circadian rhythms in mice

Oliverio, Alberto; Castellano, Claudio; Puglisi‐Allegra, Stefano

doi:10.1016/0006-8993(82)90060-9

Cited by 55 publications

(20 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in agreement with those of other investigators [Frederickson et al, 1977;Oliverio et al, 1982]. These phenomena are discussed in terms of Fig.…”

Section: Discussionsupporting

confidence: 96%

Extremely low frequency magnetic field exposure modulates the diurnal rhythm of the pain threshold in mice

Choi

Jeong

Kim

et al. 2003

Bioelectromagnetics

View full text Add to dashboard Cite

The aim of this study was to determine whether exposure to extremely low frequency magnetic field (ELF-MF) affects the normal diurnal rhythm of the pain threshold in mice. Pain thresholds were evaluated in mice using the hot plate test. A significant increase of pain threshold during night was observed compared to that during day. This rhythm was attenuated by both constant exposure to light (LL) and constant exposure to darkness (DD) for 5 days. Under DD exposure, the diurnal rhythm in pain threshold was restored when mice were exposed to ELF-MF (60 Hz, 1.5 mT for 12 h daily, from 08:00 to 20:00 h) for 5 days. The diurnal rhythm was not reversed under dark with reversed ELF-MF cycle (exposure to 1.5 mT from 20:00 to 08:00 h, next day) for 5 days, although pain threshold in the ELF-MF exposed period of night was slightly decreased. The diurnal rhythm of melatonin analgesic effect related to pain threshold was also observed under DD by the exposure of ELF-MF for 5 days, but not for 5 nights. The present results suggest that ELF-MF may participate in the diurnal rhythm of pain threshold by acting on the system that is associated with environmental light-dark cycle.

show abstract

“…These results are in agreement with those of other investigators [Frederickson et al, 1977;Oliverio et al, 1982]. These phenomena are discussed in terms of Fig.…”

Section: Discussionsupporting

confidence: 96%

Extremely low frequency magnetic field exposure modulates the diurnal rhythm of the pain threshold in mice

Choi

Jeong

Kim

et al. 2003

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…These results are in agreement with the earlier work of Lurch and Morris (1972), Frederickson et al (1977) and the more recent work of Oliverio et al (1982). The diurnal variation in nociception might be related to the circadian changes in the brain level of beta endorphin which we have established previously (Walker et al 1983;).…”

Section: Discussionsupporting

confidence: 83%

The role of opioid receptors in diabetes and hyperglycemia-induced changes in pain threshold in the rat

Akunne

Soliman

1987

Psychopharmacology

View full text Add to dashboard Cite

The role of opioid receptors in diabetes and hyperglycemia-induced analgesia was studied in male Sprague-Dawley rats. Animals maintained under controlled environmental conditions were used in all studies. Pain latency was determined by the hot plate test (55 degrees C) and analgesy-meter force method. The results of these studies indicate that streptozotocin-induced diabetic animals have a significantly higher pain threshold (P less than 0.01) than the control groups. The pain threshold was found to be diurnally controlled with a peak at the beginning of the light phase (1000 hours) and a trough at the end of the dark phase (0800 hours). Diabetes-induced analgesia was found to be reversed by both acute or chronic insulin administration. In another study, glucose-induced hyperglycemic rats were found to have a significantly higher pain threshold (P less than 0.01) than control animals, with a peak occurring at the beginning of the dark phase (2000 hours), and a trough at the beginning of the light phase (0800 hours). The administration of the opioid antagonist naloxone (2 mg/kg) reversed the hyperglycemia and diabetic-induced analgesia. The results of these studies might indicate that analgesia found in diabetic or hyperglycemic animals may be related to the endogenous opioid system.

show abstract

“…Our chronopharmacological findings are related to both activity/rest cycle and light/dark cycle. However, there is 24-h rhythm of pain sensitivity even in constant light in mice (Overio et al, 1982). The 24-h rhythm of physiological and behavioral function, including pain sensitivity, can be shifted by feeding schedule in mice (unpublished data).…”

Section: Discussionmentioning

confidence: 93%

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

Yoshida

Ohdo²,

Takane

et al. 2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

The influence of morphine dosing time on analgesic effect after acute or chronic treatment, recovery of analgesic effect after once developed tolerance, and their pharmacological mechanisms were investigated in ICR male mice under a 12-h light/ dark cycle (light on from 7:00 AM to 7:00 PM). There was a significant 24-h rhythm in the latency of thermal response at 30 min after morphine injection. The analgesic effect was significantly greater at the dark phase than at the light phase. The rhythmic pattern resembled overall the rhythm occurring in the latency of thermal response under nondrugged state. The absolute value of morphine analgesic effect (the real time spent on the hot-plate) on days 1 and 2 after morphine daily injection was significantly larger after morphine injection at 9:00 PM than after saline injection at 9:00 PM or after morphine injection at 9:00 AM. The recovery from tolerance of analgesic effect was significantly faster at the dark phase than at the light phase. The time-dependent difference in the analgesic effect after chronic treatment or recovery from tolerance is closely related to that in the expression of -opioid receptor. The present study suggests that 24-h rhythm of morphine analgesic effect is consistent with 24-h rhythm of -opioid receptor expression.A large number of physiological rhythms are controlled by the central nervous system, hormone secretion, and so on (Thomson et al., 1980;Naber et al., 1981). Also, many drugs vary in potency and/or toxicity according to the time in the 24-h cycle when they have been administered (Walker and

show abstract

Opiate analgesia: Evidence for circadian rhythms in mice

Cited by 55 publications

References 10 publications

Extremely low frequency magnetic field exposure modulates the diurnal rhythm of the pain threshold in mice

Extremely low frequency magnetic field exposure modulates the diurnal rhythm of the pain threshold in mice

The role of opioid receptors in diabetes and hyperglycemia-induced changes in pain threshold in the rat

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

Contact Info

Product

Resources

About