Opiate Analgesics

Abstract

Opiate analgesics comprise a large group of organic compounds that act on the level of the the brain. The propensity for abuse and developing dependence on drugs has led to the search for analogues free of those perils. Compounds that act as central analgesivs range all the way from congeners with complex chemical strutures derived from morphine and thebain to relatively simple organic compounds. This article ilustrates the various classes of central as well as their biological activity.

Robinson Annulation Applied to the Total Synthesis of Natural Products

“…[24] The distinctive position of codeine (22) in the modern medicine continues to stimulate endeavors to an understanding of its euphoria and also analgesic properties. [25] White et al in 1999 reported a methodology for the formation of codeine by using the intramolecular insertion reaction of a carbenoid into a benzylic methine CH bond for the construction of the C13 quaternary center and also the pentacyclic framework of the alkaloid. The total synthesis of codeine (22) was commenced from isovanillin 16 that after several steps afforded keto ester 17.…”

“…For the first time, codeine was identified by Pierre Jean Robiquet in 1832, [23] which it is known naturally in the sap of the opium poppy, Papaver somniferum [24] . The distinctive position of codeine ( 22 ) in the modern medicine continues to stimulate endeavors to an understanding of its euphoria and also analgesic properties [25] . White et al .…”