Opiate metabolism and excretion

Moore, R Andrew; Hand, C.W.; McQuay, Henry J

doi:10.1016/s0950-3501(87)80038-7

Cited by 7 publications

(5 citation statements)

References 87 publications

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“…Absorption after intramuscular injection of meperidine hydrochloride has a plasma elimination half-life of approximately 3 to 6 hours in healthy individuals. 18,19 Proper absorption of this drug is better ensured by injection in the deltoid rather than the gluteus muscle, 20 as was our practice. With respect to the control of breathing in the postoperative period for cholecystectomy, previous studies examining T i 2,3 and BF 1-3 on the first 2,3 and third 2 postoperative days after laparoscopic 3 and open 2 surgical procedures and 3 hours 1 after the former are in agreement with our findings on the second postoperative day for both surgical methods.…”

Section: Commentmentioning

confidence: 99%

Changes in Breathing Control and Mechanics After Laparoscopic vs Open Cholecystectomy

Bablekos¹

2006

Arch Surg

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Section: Commentmentioning

confidence: 99%

Changes in Breathing Control and Mechanics After Laparoscopic vs Open Cholecystectomy

Bablekos¹

2006

Arch Surg

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“…35,36 Many of these additional substances are also excreted into the faeces in an active form. 37,38 This has secondary exposure implications for veterinary staff and owners, especially when chemotherapy drugs have been used, and hygiene measures as previously described are recommended. Exposure to these other substances may also have additional clinical consequences for the dog that may affect treatment and monitoring recommendations.…”

Section: Discussionmentioning

confidence: 99%

Marijuana toxicosis in dogs in Melbourne, Australia, following suspected ingestion of human faeces: 15 cases (2011–2020)

Lauinger

Peacock

2021

Aust Veterinary J

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This retrospective case series describes a novel and unexpected source for marijuana toxicosis in dogs; suspected ingestion of human faeces containing Δ 9 -tetrahydrocannabinol (THC). Medical records from four, 24-h veterinary emergency hospitals in Melbourne, Australia, were reviewed and 15 dogs met the criteria for inclusion in this case series. Clinical signs of marijuana toxicosis included ataxia (n = 13), mydriasis (n = 6), hyperaesthesia (n = 5), urinary incontinence (n = 4) and stupor (n = 3). A urine drug screening test was performed for eight dogs and all were positive for THC. Confirmation of ingestion of human faeces was based on owner-witnessed ingestion (n = 7) or the presence of faecal material within vomit (n = 8). Sites of human faecal exposure were recorded to be a local park (n = 10), beach (n = 1), camp site (n = 1) and walking trail (n = 1). Time from exposure to development of clinical signs ranged between 3 and 6 h (n = 4). All dogs survived to discharge. Ingestion of human faeces containing THC may lead to marijuana toxicosis in dogs. Veterinary staff and owners should be attentive in regard to using appropriate hygiene measures when managing these dogs.

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“…The attenuation of fentanyl concentration in plasma follows an open two-compartment model, with a clearance rate of 11.6–13.3 (mL/kg • min) and an elimination half-life of about 2–4 hours. Moore et al 20 observed metabolites (76% in urine and 8% in feces) in approximately 80% of patients who received intravenous fentanyl. Metabolites were detected in plasma 2 minutes after administration, and the content exceeded that of the original drug 30 minutes after administration.…”

Section: Clinical Pharmacologymentioning

confidence: 99%

“…[Recommended by experts] The gradual reduction method should be adopted, with 10%~25% reduction every 3 days until the daily dose is equivalent to the dosage of 30 mg of oral morphine, ie, 12.5 μg/h fentanyl transdermal patch can be stopped after two more days of application 20 (recommendation level II, evidence level 2A, consensus level: 100.00%).…”

Section: Drug Withdrawalmentioning

confidence: 99%

Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch

Fu,

Han,

et al. 2024

DDDT

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Pain is one of the most common clinical symptoms of cancer patients, seriously affecting the quality of life of patients and bringing heavy mental and economic burden to families and society. The treatment of cancer pain in China is facing numerous challenges, one of which includes the irrational usage of analgesic drugs in clinical practice. As a strong opioid analgesic, transdermal fentanyl patch has been widely used due to its convenient clinical application and obvious therapeutic effect. Several basic-level hospitals and even general hospitals in China fail to appropriate the application of drugs in clinical application due to the lack of understanding of the pharmacological characteristics and clinical application of fentanyl transdermal patch by medical staff, seriously affecting the treatment quality. Therefore, it is imperative to strengthen the rational use and management of fentanyl transdermal patches. Accordingly, the initiation by the Cancer Rehabilitation and Palliative Treatment Professional Committee of the Hubei Anti-cancer Association launched the compilation of the “Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch” (from now on referred to as the “Guidelines”) in Hubei Province, China. The experts in the preparation group are experts in many disciplines, such as medicine, pharmacy, and nursing. The expert group determines the outline, prepares the required regulations, and revises it repeatedly. Moreover, these experts put forward suggestions for revision to strictly control the accuracy and scientific authenticity of the contents of the “Guide”. Finally, all experts of the preparation team certify and finalize the draft. This “Guide” prepared by experts of the Cancer Rehabilitation and Palliative Treatment Professional Committee of the Hubei Anti-cancer Association and the expert advisory group with joint efforts, aims to play a positive role in promoting the rational clinical use of fentanyl transdermal patch, reducing the mental and economic burden of patients, and ensuring medical quality and medical safety.

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Opiate metabolism and excretion

Cited by 7 publications

References 87 publications

Changes in Breathing Control and Mechanics After Laparoscopic vs Open Cholecystectomy

Changes in Breathing Control and Mechanics After Laparoscopic vs Open Cholecystectomy

Marijuana toxicosis in dogs in Melbourne, Australia, following suspected ingestion of human faeces: 15 cases (2011–2020)

Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch

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