Opiate receptor upregulation and functional supersensitivity.

Rs, Zukin; Tempel, Ann; El, Gardner

doi:10.1037/e474062004-001

Cited by 4 publications

(6 citation statements)

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“…1). Specifically, improved performance of naltrexone-treated rats was not reversed upon withdrawal of naltrexone, Chronic treatment with opioid antagonists up-regulates opioid receptors from 40 to 100% (Zukin et al 1984;Moudy et al 1985) and elevates levels of endogenous opioids (Ragavan et al 1983;Zukin et al 1984). Naltrexone withdrawal would be expected to produce a temporary over-stimulation of endogenous opioid systems.…”

Section: Discussionmentioning

confidence: 98%

Chronic opioids impair acquisition of both radial maze and Y-maze choice escape

1991

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Chronic morphine impaired acquisition of two dissimilar behavioral tasks. In the radial maze, the performance of saline-treated and morphine-treated groups diverged with the latter failing to improve despite extensive training. In contrast, rats treated with naltrexone became skilled in the procedure 2-4 times as rapidly as saline controls. Withdrawal of treatment significantly improved performance of morphine-treated rats, with no change for rats treated with saline or naltrexone. When a second group of rats was extensively trained prior to instituting chronic morphine treatment, performance scores were not affected, suggesting that morphine does not impair spatial working memory despite subjective evidence of other gross behavioral effects, such as ataxia. In the Y-maze choice escape task, acquisition of a response strategy was significantly impaired in rats that had been previously treated with morphine for 17-21 days, despite clear indications that morphine-treated rats were sensitive to the aversive stimulus.

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Section: Discussionmentioning

confidence: 98%

Chronic opioids impair acquisition of both radial maze and Y-maze choice escape

1991

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“…Although studies have been performed on the regulation of opioid receptors in proliferating cell lines (16) and in central nervous system tissue (17,18), results are inconsistent between the various preparations. The up-and down-regulation of opioid receptors after chronic administration of opioids has been demonstrated in several cell lines, including NG108 -15 cells (19), SK-N-SH cells (20), and SH-SY5Y cells (21).…”

mentioning

confidence: 99%

“…The up-and down-regulation of opioid receptors after chronic administration of opioids has been demonstrated in several cell lines, including NG108 -15 cells (19), SK-N-SH cells (20), and SH-SY5Y cells (21). In various brain regions, the up-regulation of opioid receptors by antagonists has been observed (17,18), whereas the effects of chronic exposure to agonist are equivocal. Down-regulation of opioid receptors in brain is observed only after exposure to nonselective agonists (22,23), whereas selective opioid agonists produced either no change (24,25) or an increase in the number of receptors (26) Opioid peptides (DAMGO and DPDPE) were from Peninsula Laboratories (Belmont, CA).…”

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confidence: 99%

Regulation of Opioid Receptors in Rat Sensory Neurons in Culture

1997

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SUMMARYTo determine whether opioid receptors in sensory neurons are regulated by chronic exposure to opioids, we assessed the binding of various opioid ligands to membranes derived from isolated rat dorsal root ganglia neurons grown in culture. ]diprenorphine binding sites, respectively. Preexposure of neurons to 10 M naloxone for 48 hr up-regulated the receptors by 40%, whereas incubation with 100 nM to 10 M DAMGO for 48 hr resulted in a significant decrease in the B max value of opioid receptors, with a maximum reduction of 70%. The identification of a high level of opioid receptors expressed in isolated sensory neurons and their modulation by opioids demonstrates that cultured sensory neurons are an excellent model with which to study opioid receptor regulation.

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“…The agonists of ~:-and 8-opiate receptors completely prevented ventricular fibrillation. This effect is probably related to modulation of sympathetic nerve activity and metabolism in ischemic myocardium by selective opioid peptides [7,8]. A less pronounced protective effect of ~t-receptor agonist DAGO can be explained by its capacity to increase blood catecholamine level [6].…”

Section: Resultsmentioning

confidence: 99%

Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists

et al. 2000

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In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A(1-13) on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor cortex. The most pronounced effects were observed with DSLET and dinorphin A(1-13). These preparations completely prevented ventricular fibrillation. DAGO produced a less pronounced protective effect probably because of parallel increase in plasma catecholamine concentration.

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Opiate receptor upregulation and functional supersensitivity.

Cited by 4 publications

References 0 publications

Chronic opioids impair acquisition of both radial maze and Y-maze choice escape

Chronic opioids impair acquisition of both radial maze and Y-maze choice escape

Regulation of Opioid Receptors in Rat Sensory Neurons in Culture

Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists

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