Opiates and Acute Abdominal Pain—Reply

Objective To assess the performance of novel contour enhanced funnel plots and a regression based adjustment method to detect and adjust for publication biases. Design Secondary analysis of a published systematic literature review. Data sources Placebo controlled trials of antidepressants previously submitted to the US Food and Drug Administration (FDA) and matching journal publications. Methods Publication biases were identified using novel contour enhanced funnel plots, a regression based adjustment method, Egger's test, and the trim and fill method. Results were compared with a meta-analysis of the gold standard data submitted to the FDA. Results Severe asymmetry was observed in the contour enhanced funnel plot that appeared to be heavily influenced by the statistical significance of results, suggesting publication biases as the cause of the asymmetry. Applying the regression based adjustment method to the journal data produced a similar pooled effect to that observed by a meta-analysis of the FDA data.

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Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications

Moreno

Sutton

Turner

et al. 2009

BMJ

160

146

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The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews

Kirkham

Dwan

Altman

et al. 2010

BMJ

975

599

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Drug treatment for generalised anxiety disorder

Furukawa¹

2011

BMJ

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Opiates and Acute Abdominal Pain—Reply

Cited by 4 publications

References 1 publication

Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications

Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications

The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews

Drug treatment for generalised anxiety disorder

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