Opinion on the recent development of injectable biomaterials for treating myocardial infarction

Wang, Wei; Liang, Shuang; Liu, Wenguang

doi:10.1007/s11431-017-9064-7

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…MI is most common in Europe and the United States, with about 1.5 million people suffering from it each year in the United States. China has shown a clear upward trend in recent years, with at least 500,000 new issues each year and a current incidence of at least 2 million [ 5 , 6 ]. The primary objective of treatment of MI is clearance of the blocked coronary artery and restoration of function of ischemic and hypoxic myocardium [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA SNHG8 Plays a Key Role in Myocardial Infarction Through Affecting Hypoxia-Induced Cardiomyocyte Injury

Zhang

Bian

2020

Med Sci Monit

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Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA SNHG8 Plays a Key Role in Myocardial Infarction Through Affecting Hypoxia-Induced Cardiomyocyte Injury

Zhang

Bian

2020

Med Sci Monit

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“…It is interesting to find that the hydrogel completely infiltrates and fuses within the myocardium tissue, evidencing an excellent adhesion ability, which is a favorable precondition for the treatment of MI. The hydrogel is degraded mostly at 4 weeks, which is beneficial for the repair of the myocardium, since the adhesive would become a burden after long‐term attachment on the heart . The mechanism for the degradation is based on the fact that our hydrogel system is mainly composed of pyrrole‐terminated poly (β‐amino esters) and gelatin.…”

mentioning

confidence: 99%

Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

et al. 2018

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In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe -triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage. The functional patch whose conductivity is equivalent to that of normal myocardium is strongly bonded to the beating heart within 4 weeks, accordingly efficiently boosting the transmission of electrophysiological signals. Eventually, the reconstruction of cardiac function and revascularization of the infarct myocardium are remarkably improved. The translatable suture-free strategy reported in this work is promising to address the human clinical challenges in cardiac tissue engineering.

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“…Overall, graphene-based nanomaterials hold great promise for applications in cardiac tissue engineering. Most synthetic hydrogels used for tissue engineering are mechanically weak and lack conductive properties 33 - 36 . The addition of graphene-based nanoparticles imparted the required conductivity and surface properties to these hydrogel materials in several ways and further improved the microenvironment of the infarcted region 13 - 15 , 32 .…”

Section: Discussionmentioning

confidence: 99%

Injectable OPF/graphene oxide hydrogels provide mechanical support and enhance cell electrical signaling after implantation into myocardial infarct

Zhou¹,

Yang²,

Liu³

et al. 2018

Theranostics

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After myocardial infarction (MI), the scar tissue contributes to ventricular dysfunction by electrically uncoupling viable cardiomyocytes in the infarct region. Injection of a conductive hydrogel could not only provide mechanical support to the infarcted region, but also synchronize contraction and restore ventricular function by electrically connecting isolated cardiomyocytes to intact tissue.Methods: We created a conductive hydrogel by introducing graphene oxide (GO) nanoparticles into oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels. The hydrogels were characterized by AFM and electrochemistry workstation. A rat model of myocardial infarction was used to investigate the ability of OPF/GO to improve cardiac electrical propagation in the injured heart in vivo. Echocardiography (ECHO) was used to evaluate heart function 4 weeks after MI. Ca2+ imaging was used to visualize beating cardiomyocytes (CMs). Immunofluorescence staining was used to visualize the expression of cardiac-specific markers.Results: OPF/GO hydrogels had semiconductive properties that were lacking in pure OPF. In addition, the incorporation of GO into OPF hydrogels could improve cell attachment in vitro. Injection of OPF/GO 4 weeks after myocardial infarction in rats enhanced the Ca2+ signal conduction of cardiomyocytes in the infarcted region in comparison with PBS or OPF alone. Moreover, the injection of OPF/GO hydrogel into the infarct region enhanced the generation of cytoskeletal structure and intercalated disc assembly. Echocardiography analysis showed improvement in load-dependent ejection fraction/fractional shortening of heart function 4 weeks after injection.Conclusions: We prepared a conductive hydrogel (OPF/GO) that provide mechanical support and biological conduction in vitro and in vivo. We found that injected OPF/GO hydrogels can provide mechanical support and electric connection between healthy myocardium and the cardiomyocytes in the scar via activating the canonical Wnt signal pathway, thus upregulating the generation of Cx43 and gap junction associated proteins. Injection of OPF/GO hydrogel maintained better heart function after myocardial infarction than the injection of a nonconductive polymer.

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Opinion on the recent development of injectable biomaterials for treating myocardial infarction

Cited by 5 publications

References 10 publications

Long Non-Coding RNA SNHG8 Plays a Key Role in Myocardial Infarction Through Affecting Hypoxia-Induced Cardiomyocyte Injury

Long Non-Coding RNA SNHG8 Plays a Key Role in Myocardial Infarction Through Affecting Hypoxia-Induced Cardiomyocyte Injury

Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

Injectable OPF/graphene oxide hydrogels provide mechanical support and enhance cell electrical signaling after implantation into myocardial infarct

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